tert-butyl 2-azido-4'-tert-butylcinnamate

Base Information

• Chemical Name: tert-butyl 2-azido-4'-tert-butylcinnamate
• CAS No.: 250213-52-6
• Molecular Formula: C₁₇H₂₃N₃O₂
• Molecular Weight: 301.389
• Mol file: 250213-52-6.mol

Synonyms:tert-butyl 2-azido-4'-tert-butylcinnamate

Chemical Property of tert-butyl 2-azido-4'-tert-butylcinnamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-azido-4'-tert-butylcinnamate

There total 3 articles about tert-butyl 2-azido-4'-tert-butylcinnamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

tert-butyl 2-azido-3-(tert-butylphenyl)-3-hydroxypropionate (250213-47-9) → tert-butyl 2-azido-4'-tert-butylcinnamate (250213-52-6)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at -40 ℃; for 0.166667h;

DOI:10.1248/cpb.47.1227

Reference yield:

4-tert-Butylbenzaldehyde (939-97-9) → tert-butyl 2-azido-4'-tert-butylcinnamate (250213-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / i-PrONa / propan-2-ol / 4 h / -30 °C

2: 81 percent / Et₃N; MsCl / CH₂Cl₂ / 0.17 h / -40 °C

With sodium isopropylate; methanesulfonyl chloride; triethylamine; In dichloromethane; isopropyl alcohol; 1: Condensation / 2: Dehydration;

DOI:10.1248/cpb.47.1227

Reference yield:

tert-butyl 2-azidoacetate (6367-36-8) → tert-butyl 2-azido-4'-tert-butylcinnamate (250213-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / i-PrONa / propan-2-ol / 4 h / -30 °C

2: 81 percent / Et₃N; MsCl / CH₂Cl₂ / 0.17 h / -40 °C

With sodium isopropylate; methanesulfonyl chloride; triethylamine; In dichloromethane; isopropyl alcohol; 1: Condensation / 2: Dehydration;

DOI:10.1248/cpb.47.1227

upstream raw materials:

tert-butyl 2-azido-3-(tert-butylphenyl)-3-hydroxypropionate

tert-butyl 2-azidoacetate

4-tert-Butylbenzaldehyde