5-(tert-butylimino)-10-chloro-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

Base Information

• Chemical Name: 5-(tert-butylimino)-10-chloro-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one
• CAS No.: 1452386-67-2
• Molecular Formula: C₂₆H₂₅ClN₄O
• Molecular Weight: 444.964

Synonyms:5-(tert-butylimino)-10-chloro-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

Chemical Property of 5-(tert-butylimino)-10-chloro-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

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Technology Process of 5-(tert-butylimino)-10-chloro-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one

There total 3 articles about 5-(tert-butylimino)-10-chloro-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

tert-butylisonitrile (119072-55-8,7188-38-7) + 2-(2-bromophenyl)-6-chloro-1-methyl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one (1452386-56-9) → 5-(tert-butylimino)-10-chloro-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one (1452386-67-2)

Guidance literature:

With palladium diacetate; caesium carbonate; In toluene; at 110 ℃; for 24h; Sealed tube;

DOI:10.1055/s-0033-1338936

Reference yield:

phenylhydrazine (100-63-0) → 5-(tert-butylimino)-10-chloro-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one (1452386-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile / Reflux

1.2: 81 °C

2.1: palladium diacetate; caesium carbonate / toluene / 24 h / 110 °C / Sealed tube

With palladium diacetate; caesium carbonate; In toluene; acetonitrile;

DOI:10.1055/s-0033-1338936

Reference yield:

6-chloro-N-methylisatoic anhydride (14529-12-5) + ortho-bromobenzaldehyde (6630-33-7) → 5-(tert-butylimino)-10-chloro-13-methyl-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one (1452386-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile / Reflux

1.2: 81 °C

2.1: palladium diacetate; caesium carbonate / toluene / 24 h / 110 °C / Sealed tube

With palladium diacetate; caesium carbonate; In toluene; acetonitrile;

DOI:10.1055/s-0033-1338936

upstream raw materials:

6-chloro-N-methylisatoic anhydride

ortho-bromobenzaldehyde

tert-butylisonitrile

2-(2-bromophenyl)-6-chloro-1-methyl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one

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