5-tert-butyl-2-(3-(5-(5-(3-hydroxyazetidin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)isoindolin-1-one

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Chemical Name:5-tert-butyl-2-(3-(5-(5-(3-hydroxyazetidin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)isoindolin-1-one
CAS No.:1361941-25-4
Molecular Formula:C₃₃H₃₅N₅O₄
Molecular Weight:565.672
Hs Code.:

Synonyms:5-tert-butyl-2-(3-(5-(5-(3-hydroxyazetidin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)isoindolin-1-one

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Chemical Property of 5-tert-butyl-2-(3-(5-(5-(3-hydroxyazetidin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)isoindolin-1-one

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Technology Process of 5-tert-butyl-2-(3-(5-(5-(3-hydroxyazetidin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)isoindolin-1-one

There total 8 articles about 5-tert-butyl-2-(3-(5-(5-(3-hydroxyazetidin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1346673-20-8
5-bromo-3-((5-(3-hydroxyazetidin-1-yl)pyridin-2-yl)amino)-1-methylpyridin-2(1H)-one

: 1361386-56-2
2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

: 1361941-25-4
5-tert-butyl-2-(3-(5-(5-(3-hydroxyazetidin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)isoindolin-1-one

Guidance literature:: 5-bromo-3-((5-(3-hydroxyazetidin-1-yl)pyridin-2-yl)amino)-1-methylpyridin-2(1H)-one; 2-(5-tert-butyl-1-oxoisoindolin-2-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate; With sodium carbonate; In 1,4-dioxane; water; for 0.5h; Reflux; Inert atmosphere;

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 3h;

Reference yield:

: 93701-32-7
2,6-dibromobenzyl bromide

: 1361941-25-4
5-tert-butyl-2-(3-(5-(5-(3-hydroxyazetidin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 14 h / 20 °C / Inert atmosphere

2.1: caesium carbonate; N,N-dimethylethylenediamine / 1,4-dioxane / 0.5 h / Inert atmosphere; Reflux

2.2: 14 h / 105 °C

3.1: potassium acetate / 1,4-dioxane / 0.5 h / Reflux; Inert atmosphere

3.2: 14 h / 105 °C

4.1: sodium carbonate / 1,4-dioxane; water / 0.5 h / Reflux; Inert atmosphere

4.2: 3 h / 100 °C

With potassium acetate; sodium carbonate; caesium carbonate; N,N-dimethylethylenediamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1361386-52-8
4-(tert-butyl)-N,N-diethyl-2-formylbenzamide

: 1361941-25-4
5-tert-butyl-2-(3-(5-(5-(3-hydroxyazetidin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid; triethylsilane / acetonitrile / 1.5 h / 130 °C / Microwave irraradiation

2.1: lithium hydroxide / tetrahydrofuran; methanol / 2.5 h / 110 °C / Microwave irradiation

2.2: pH 7

3.1: caesium carbonate; N,N-dimethylethylenediamine / 1,4-dioxane / 0.5 h / Inert atmosphere; Reflux

3.2: 14 h / 105 °C

4.1: potassium acetate / 1,4-dioxane / 0.5 h / Reflux; Inert atmosphere

4.2: 14 h / 105 °C

5.1: sodium carbonate / 1,4-dioxane; water / 0.5 h / Reflux; Inert atmosphere

5.2: 3 h / 100 °C

With triethylsilane; potassium acetate; sodium carbonate; caesium carbonate; N,N-dimethylethylenediamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile;