diethyl 2-(2-(4-chlorophenyl)-1-(5,6,7,8-tetrahydronaphthalen-1-ylamino)ethylidene)malonate

Base Information

Chemical Name:diethyl 2-(2-(4-chlorophenyl)-1-(5,6,7,8-tetrahydronaphthalen-1-ylamino)ethylidene)malonate
CAS No.:924633-62-5
Molecular Formula:C₂₅H₂₈ClNO₄
Molecular Weight:441.955
Hs Code.:

Synonyms:diethyl 2-(2-(4-chlorophenyl)-1-(5,6,7,8-tetrahydronaphthalen-1-ylamino)ethylidene)malonate

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Chemical Property of diethyl 2-(2-(4-chlorophenyl)-1-(5,6,7,8-tetrahydronaphthalen-1-ylamino)ethylidene)malonate

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Technology Process of diethyl 2-(2-(4-chlorophenyl)-1-(5,6,7,8-tetrahydronaphthalen-1-ylamino)ethylidene)malonate

There total 4 articles about diethyl 2-(2-(4-chlorophenyl)-1-(5,6,7,8-tetrahydronaphthalen-1-ylamino)ethylidene)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 924633-61-4
(E)-2-(4-chlorophenyl)-N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetimidoyl chloride

: 105-53-3
diethyl malonate

: 924633-62-5
diethyl 2-(2-(4-chlorophenyl)-1-(5,6,7,8-tetrahydronaphthalen-1-ylamino)ethylidene)malonate

Guidance literature:: diethyl malonate; With sodium hydride; In toluene; at 20 - 110 ℃; for 1h;

(E)-2-(4-chlorophenyl)-N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetimidoyl chloride; In toluene; for 15h; Heating;
DOI:10.1021/jm060631p

Reference yield:

: 924633-60-3
2-(4-chlorophenyl)-N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetamide

: 924633-62-5
diethyl 2-(2-(4-chlorophenyl)-1-(5,6,7,8-tetrahydronaphthalen-1-ylamino)ethylidene)malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: PCl₅ / 4 h / 65 °C

2.1: NaH / toluene / 1 h / 20 - 110 °C

2.2: toluene / 15 h / Heating

With phosphorus pentachloride; sodium hydride; In toluene;
DOI:10.1021/jm060631p

Reference yield:

: 1878-66-6
4-chlorophenylacetic Acid

: 924633-62-5
diethyl 2-(2-(4-chlorophenyl)-1-(5,6,7,8-tetrahydronaphthalen-1-ylamino)ethylidene)malonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl chloride; DMF / tetrahydrofuran / 1 h

2.1: 90 percent / i-Pr₂NEt / CH₂Cl₂ / 20 °C

3.1: PCl₅ / 4 h / 65 °C

4.1: NaH / toluene / 1 h / 20 - 110 °C

4.2: toluene / 15 h / Heating

With oxalyl dichloride; phosphorus pentachloride; sodium hydride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm060631p