4-methylpiperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Base Information

• Chemical Name: 4-methylpiperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester
• CAS No.: 705966-33-2
• Molecular Formula: C₁₅H₂₀N₂O₄
• Molecular Weight: 292.335
• Mol file: 705966-33-2.mol

Synonyms:4-methylpiperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Chemical Property of 4-methylpiperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methylpiperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

There total 3 articles about 4-methylpiperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + piperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (126937-43-7,1217598-28-1) → 4-methylpiperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (705966-33-2)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

DOI:10.1016/j.tetasy.2004.02.028

Reference yield:

methyl phosphite (96-36-6,868-85-9) + piperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (126937-43-7,1217598-28-1) + benzaldehyde (100-52-7) → 4-methylpiperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (705966-33-2) + 2-methyl 1-phenylmethyl 4-<(dimethoxyphosphinyl)phenylmethyl>-1,2-piperazinedicarboxylate (129365-32-8,129365-33-9)

Guidance literature:

In acetonitrile; at 80 ℃; for 48h; Yields of byproduct given;

DOI:10.1021/jm00172a037

Reference yield:

piperazine-1,2,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester 2-methyl ester (126937-42-6,1211399-66-4) → 4-methylpiperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (705966-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / TFA / CH₂Cl₂ / 3 h / 20 °C

2: 99 percent / NaB(OAc)3H / 1,2-dichloro-ethane / 20 °C

With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1016/j.tetasy.2004.02.028

upstream raw materials:

methyl phosphite

piperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

benzaldehyde

formaldehyd