(3R,3'R,5'R)-1-methyl-3',5'-bis(2-oxo-2-phenylethyl)-5',6'-dihydrospiro[indoline-3,4'-pyran]-2,2'(3'H)-dione

Base Information

Chemical Name:(3R,3'R,5'R)-1-methyl-3',5'-bis(2-oxo-2-phenylethyl)-5',6'-dihydrospiro[indoline-3,4'-pyran]-2,2'(3'H)-dione
CAS No.:1579957-36-0
Molecular Formula:C₂₉H₂₅NO₅
Molecular Weight:467.521
Hs Code.:

Synonyms:(3R,3'R,5'R)-1-methyl-3',5'-bis(2-oxo-2-phenylethyl)-5',6'-dihydrospiro[indoline-3,4'-pyran]-2,2'(3'H)-dione

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Chemical Property of (3R,3'R,5'R)-1-methyl-3',5'-bis(2-oxo-2-phenylethyl)-5',6'-dihydrospiro[indoline-3,4'-pyran]-2,2'(3'H)-dione

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Technology Process of (3R,3'R,5'R)-1-methyl-3',5'-bis(2-oxo-2-phenylethyl)-5',6'-dihydrospiro[indoline-3,4'-pyran]-2,2'(3'H)-dione

There total 10 articles about (3R,3'R,5'R)-1-methyl-3',5'-bis(2-oxo-2-phenylethyl)-5',6'-dihydrospiro[indoline-3,4'-pyran]-2,2'(3'H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 61-70-1
N-methyl-2-indolinone

: 1579957-18-8
(E)-(E)-4-oxo-4-phenylbut-2-en-1-yl 4-oxo-4-phenylbut-2-enoate

: 1579957-36-0
(3R,3'R,5'R)-1-methyl-3',5'-bis(2-oxo-2-phenylethyl)-5',6'-dihydrospiro[indoline-3,4'-pyran]-2,2'(3'H)-dione

Guidance literature:: With C₁₉H₂₅F₆N₃S; In toluene; at 20 ℃; for 72h; Reagent/catalyst; Solvent; enantioselective reaction;
DOI:10.1021/ol500547e

Reference yield: 78.0%

: 61-70-1
N-methyl-2-indolinone

: 1579957-18-8
(E)-(E)-4-oxo-4-phenylbut-2-en-1-yl 4-oxo-4-phenylbut-2-enoate

: 1579957-90-6
(3S,3'S,5'S)-1-methyl-3',5'-bis(2-oxo-2-phenylethyl)-5',6'-dihydrospiro[indoline-3,4'-pyran]-2,2'(3'H)-dione

: 1579957-36-0
(3R,3'R,5'R)-1-methyl-3',5'-bis(2-oxo-2-phenylethyl)-5',6'-dihydrospiro[indoline-3,4'-pyran]-2,2'(3'H)-dione

Guidance literature:: With C₁₉H₂₅F₆N₃S; In tetrahydrofuran; at 20 ℃; for 72h; enantioselective reaction;
DOI:10.1021/ol500547e

Reference yield:

: 98-86-2
acetophenone

: 1579957-36-0
(3R,3'R,5'R)-1-methyl-3',5'-bis(2-oxo-2-phenylethyl)-5',6'-dihydrospiro[indoline-3,4'-pyran]-2,2'(3'H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; hydrogenchloride / 18 h / Reflux

2: dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

3: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Reflux

4: dichloromethane / 20 °C

5: C₁₉H₂₅F₆N₃S / toluene / 72 h / 20 °C

With hydrogenchloride; C₁₉H₂₅F₆N₃S; acetic acid; dicyclohexyl-carbodiimide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; ethyl acetate; toluene; 5: |Michael Addition;
DOI:10.1021/ol500547e