N-(2-METHOXY-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE

Base Information

• Chemical Name: N-(2-METHOXY-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE
• CAS No.: 898561-71-2
• Molecular Formula: C₁₁H₁₆N₂O₂
• Molecular Weight: 208.26
• Hs Code.: 2933399090
• Mol file: 898561-71-2.mol

Synonyms:N-(2-METHOXY-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE

Chemical Property of N-(2-METHOXY-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE

Chemical Property:

• Vapor Pressure: 2.14E-05mmHg at 25°C
• Refractive Index: 1.537
• Boiling Point: 360.9°C at 760 mmHg
• PKA: 13.44±0.70(Predicted)
• Flash Point: 172.1°C
• PSA: 51.22000
• Density: 1.1g/cm³
• LogP: 2.14780

Purity/Quality:

98%min ^*data from raw suppliers

N-(2-Methoxy-pyridin-4-yl)-2,2-dimethyl-propionamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-METHOXY-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE

There total 1 articles about N-(2-METHOXY-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.7%

4-amino-2-methoxypyridine (20265-39-8) + pivaloyl chloride (3282-30-2) → C11H16N2O2 (898561-71-2)

Guidance literature:

With triethylamine; In N,N-dimethyl acetamide; at 5 - 25 ℃; for 5.5h; Inert atmosphere; Large scale;

Reference yield: 80.0%

C11H16N2O2 (898561-71-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → C12H16N2O3

Guidance literature:

C₁₁H₁₆N₂O₂; In tetrahydrofuran; at 15 - 25 ℃; for 0.166667h; Inert atmosphere; Large scale;

With n-hexyllithium; In tetrahydrofuran; hexane; at 4 ℃; for 13.5h; Inert atmosphere; Large scale;

N,N-dimethyl-formamide; In tetrahydrofuran; at 4 ℃; for 10.7h; Inert atmosphere; Large scale;

Reference yield:

C11H16N2O2 (898561-71-2) → AMG 337 (1173699-31-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 0.17 h / 15 - 25 °C / Inert atmosphere; Large scale

1.2: 13.5 h / 4 °C / Inert atmosphere; Large scale

1.3: 10.7 h / 4 °C / Inert atmosphere; Large scale

2.1: sodium hydroxide / water; ethanol / 2 h / 20 - 65 °C / Large scale

3.1: hydrogenchloride / water / 3.16 h / 15 - 60 °C / Inert atmosphere; Large scale

4.1: magnesium 2-methylpropan-2-olate; potassium tert-butylate / tetrahydrofuran / 12.58 h / 25 - 30 °C / Inert atmosphere; Large scale

4.2: 20 - 60 °C / Inert atmosphere; Large scale

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 10 - 35 °C / Inert atmosphere; Large scale

6.1: Lawessons reagent / acetonitrile; water / 50 °C / Inert atmosphere

With Lawessons reagent; hydrogenchloride; potassium tert-butylate; magnesium 2-methylpropan-2-olate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide; water; acetonitrile;

upstream raw materials:

4-amino-2-methoxypyridine

pivaloyl chloride

Downstream raw materials:

AMG 337

Refernces