1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitro-2-(diphenylphosphatoxy)-butane

Base Information

Chemical Name:1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitro-2-(diphenylphosphatoxy)-butane
CAS No.:904325-42-4
Molecular Formula:C₃₅H₃₉N₂O₈P
Molecular Weight:646.677
Hs Code.:

Synonyms:1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitro-2-(diphenylphosphatoxy)-butane

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Chemical Property of 1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitro-2-(diphenylphosphatoxy)-butane

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Technology Process of 1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitro-2-(diphenylphosphatoxy)-butane

There total 5 articles about 1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitro-2-(diphenylphosphatoxy)-butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 904325-41-3
1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitrobutan-2-ol

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 904325-42-4
1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitro-2-(diphenylphosphatoxy)-butane

Guidance literature:: With dmap; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tet.2006.03.063

Reference yield:

: 904325-40-2
2-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}ethanal

: 904325-42-4
1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitro-2-(diphenylphosphatoxy)-butane

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / potassium tert-butoxide / acetonitrile; 2-methyl-propan-2-ol

2: 94 percent / DMAP / CH₂Cl₂ / 20 °C

With dmap; potassium tert-butylate; In dichloromethane; acetonitrile; tert-butyl alcohol; 1: Henry reaction;
DOI:10.1016/j.tet.2006.03.063

Reference yield:

: 904325-39-9
2-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}ethanol

: 904325-42-4
1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitro-2-(diphenylphosphatoxy)-butane

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / PCC; molecular sieves 4 Angstroem / CH₂Cl₂

2: 92 percent / potassium tert-butoxide / acetonitrile; 2-methyl-propan-2-ol

3: 94 percent / DMAP / CH₂Cl₂ / 20 °C

With dmap; 4 A molecular sieve; potassium tert-butylate; pyridinium chlorochromate; In dichloromethane; acetonitrile; tert-butyl alcohol; 2: Henry reaction;
DOI:10.1016/j.tet.2006.03.063