1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitrobutan-2-ol

Base Information

Chemical Name:1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitrobutan-2-ol
CAS No.:904325-41-3
Molecular Formula:C₂₃H₃₀N₂O₅
Molecular Weight:414.502
Hs Code.:

Synonyms:1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitrobutan-2-ol

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Chemical Property of 1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitrobutan-2-ol

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Technology Process of 1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitrobutan-2-ol

There total 4 articles about 1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitrobutan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 904325-40-2
2-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}ethanal

: 79-46-9
2-nitropropane

: 904325-41-3
1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitrobutan-2-ol

Guidance literature:: With potassium tert-butylate; In acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tet.2006.03.063

Reference yield:

: 904325-39-9
2-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}ethanol

: 904325-41-3
1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitrobutan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / PCC; molecular sieves 4 Angstroem / CH₂Cl₂

2: 92 percent / potassium tert-butoxide / acetonitrile; 2-methyl-propan-2-ol

With 4 A molecular sieve; potassium tert-butylate; pyridinium chlorochromate; In dichloromethane; acetonitrile; tert-butyl alcohol; 2: Henry reaction;
DOI:10.1016/j.tet.2006.03.063

Reference yield:

: 100-39-0
benzyl bromide

: 904325-41-3
1-{2-[N-benzyl-N-(tert-butyloxycarbonyl)amino]phenyl}-3-methyl-3-nitrobutan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / NaH / dimethylformamide; various solvent(s) / cooling

2: 63 percent / PCC; molecular sieves 4 Angstroem / CH₂Cl₂

3: 92 percent / potassium tert-butoxide / acetonitrile; 2-methyl-propan-2-ol

With 4 A molecular sieve; potassium tert-butylate; sodium hydride; pyridinium chlorochromate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 3: Henry reaction;
DOI:10.1016/j.tet.2006.03.063