2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetic acid

Base Information

Chemical Name:2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetic acid
CAS No.:1227484-15-2
Molecular Formula:C₁₈H₃₀O₆Si
Molecular Weight:370.518
Hs Code.:

Synonyms:2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetic acid

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Chemical Property of 2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetic acid

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Technology Process of 2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetic acid

There total 3 articles about 2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1227484-35-6
2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetaldehyde

: 1227484-15-2
2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetic acid

Guidance literature:: With sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2010.02.089

Reference yield: 99.0%

: 1337973-19-9
ethyl (5-(tert-butyldimethylsilanyloxymethyl)-4-methoxy-2-methoxymethoxyphenyl)acetate

: 1227484-15-2
2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetic acid

Guidance literature:: ethyl (5-(tert-butyldimethylsilanyloxymethyl)-4-methoxy-2-methoxymethoxyphenyl)acetate; With sodium hydroxide; In ethanol; at 40 ℃; for 16h; Inert atmosphere;

With hydrogenchloride; In ethanol; water; pH=3 - 4; Inert atmosphere;
DOI:10.1007/s12272-011-0805-9

Reference yield:

: 1227484-31-2
(5-bromo-2-methoxy-4-(methoxymethoxy)benzyloxy)(tert-butyl)dimethylsilane

: 1227484-15-2
2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichlorobis(tri-O-tolylphosphine)palladium; zinc dibromide / N,N-dimethyl-formamide / 14 h / 80 °C / Inert atmosphere

2.1: sodium hydroxide / ethanol / 16 h / 40 °C / Inert atmosphere

2.2: pH 3 - 4 / Inert atmosphere

With dichlorobis(tri-O-tolylphosphine)palladium; sodium hydroxide; zinc dibromide; In ethanol; N,N-dimethyl-formamide; 1.1: Negishi-Reformatsky coupling;
DOI:10.1007/s12272-011-0805-9