(S)-2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)propanoic acid

Base Information

Chemical Name:(S)-2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)propanoic acid
CAS No.:1337973-15-5
Molecular Formula:C₁₉H₃₂O₆Si
Molecular Weight:384.545
Hs Code.:

Synonyms:(S)-2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)propanoic acid

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Chemical Property of (S)-2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)propanoic acid

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Technology Process of (S)-2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)propanoic acid

There total 5 articles about (S)-2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1337973-21-3
(S)-4-benzyl-3-((S)-2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)propanoyl)oxazolidin-2-one

: 1337973-15-5
(S)-2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)propanoic acid

Guidance literature:: (S)-4-benzyl-3-((S)-2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)propanoyl)oxazolidin-2-one; With lithium hydroxide monohydrate; dihydrogen peroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; In water; pH=2 - 3; Inert atmosphere;
DOI:10.1007/s12272-011-0805-9

Reference yield:

: 1227484-15-2
2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetic acid

: 1337973-15-5
(S)-2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 1.25 h / -78 - 0 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; diethyl ether / 0.67 h / -78 °C / Inert atmosphere

2.2: 2.25 h / -78 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.2 h / -78 °C / Inert atmosphere

3.2: 6 h / -78 - 20 °C / Inert atmosphere

4.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 4 h / 0 - 20 °C / Inert atmosphere

4.2: pH 2 - 3 / Inert atmosphere

With n-butyllithium; lithium hydroxide monohydrate; dihydrogen peroxide; sodium hexamethyldisilazane; triethylamine; In tetrahydrofuran; diethyl ether; water;
DOI:10.1007/s12272-011-0805-9

Reference yield:

: C₂₃H₃₈O₇Si

: 1337973-15-5
(S)-2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; diethyl ether / 0.67 h / -78 °C / Inert atmosphere

1.2: 2.25 h / -78 - 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.2 h / -78 °C / Inert atmosphere

2.2: 6 h / -78 - 20 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 4 h / 0 - 20 °C / Inert atmosphere

3.2: pH 2 - 3 / Inert atmosphere

With n-butyllithium; lithium hydroxide monohydrate; dihydrogen peroxide; sodium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; water;
DOI:10.1007/s12272-011-0805-9