(S)-4-benzyl-3-(2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetyl)oxazolidin-2-one

Base Information

Chemical Name:(S)-4-benzyl-3-(2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetyl)oxazolidin-2-one
CAS No.:1337973-17-7
Molecular Formula:C₂₈H₃₉NO₇Si
Molecular Weight:529.706
Hs Code.:

Synonyms:(S)-4-benzyl-3-(2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetyl)oxazolidin-2-one

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Chemical Property of (S)-4-benzyl-3-(2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetyl)oxazolidin-2-one

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Technology Process of (S)-4-benzyl-3-(2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetyl)oxazolidin-2-one

There total 3 articles about (S)-4-benzyl-3-(2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₃₈O₇Si

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 1337973-17-7
(S)-4-benzyl-3-(2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetyl)oxazolidin-2-one

Guidance literature:: (S)-4-Benzyl-2-oxazolidinone; With n-butyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.666667h; Inert atmosphere;

C₂₃H₃₈O₇Si; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; for 2.25h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; diethyl ether; water; Inert atmosphere;
DOI:10.1007/s12272-011-0805-9

Reference yield:

: 1227484-15-2
2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetic acid

: 1337973-17-7
(S)-4-benzyl-3-(2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 1.25 h / -78 - 0 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; diethyl ether / 0.67 h / -78 °C / Inert atmosphere

2.2: 2.25 h / -78 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

With n-butyllithium; triethylamine; In tetrahydrofuran; diethyl ether;
DOI:10.1007/s12272-011-0805-9

Reference yield:

: 1227484-31-2
(5-bromo-2-methoxy-4-(methoxymethoxy)benzyloxy)(tert-butyl)dimethylsilane

: 1337973-17-7
(S)-4-benzyl-3-(2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichlorobis(tri-O-tolylphosphine)palladium; zinc dibromide / N,N-dimethyl-formamide / 14 h / 80 °C / Inert atmosphere

2.1: sodium hydroxide / ethanol / 16 h / 40 °C / Inert atmosphere

2.2: pH 3 - 4 / Inert atmosphere

3.1: triethylamine / tetrahydrofuran / 1.25 h / -78 - 0 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; diethyl ether / 0.67 h / -78 °C / Inert atmosphere

4.2: 2.25 h / -78 - 20 °C / Inert atmosphere

4.3: Inert atmosphere

With n-butyllithium; dichlorobis(tri-O-tolylphosphine)palladium; triethylamine; sodium hydroxide; zinc dibromide; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; 1.1: Negishi-Reformatsky coupling;
DOI:10.1007/s12272-011-0805-9