1-(4-(2-(6-(1,3-dioxan-2-yl)pyridin-3-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

Base Information

Chemical Name:1-(4-(2-(6-(1,3-dioxan-2-yl)pyridin-3-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea
CAS No.:1342869-12-8
Molecular Formula:C₂₆H₂₃FN₄O₄S
Molecular Weight:506.557
Hs Code.:

Synonyms:1-(4-(2-(6-(1,3-dioxan-2-yl)pyridin-3-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

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Chemical Property of 1-(4-(2-(6-(1,3-dioxan-2-yl)pyridin-3-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

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Technology Process of 1-(4-(2-(6-(1,3-dioxan-2-yl)pyridin-3-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

There total 2 articles about 1-(4-(2-(6-(1,3-dioxan-2-yl)pyridin-3-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1342869-10-6
4-(2-(6-(1,3-dioxan-2-yl)pyridin-3-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluoroaniline

: 1885-14-9
phenyl chloroformate

: 765-30-0
Cyclopropylamine

: 1342869-12-8
1-(4-(2-(6-(1,3-dioxan-2-yl)pyridin-3-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: With pyridine; ammonium hydroxide; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide;

Reference yield:

: 1342869-06-0
2-(6-(1,3-dioxan-2-yl)pyridin-3-yl)-7-chlorothieno[3,2-b]pyridine

: 1342869-12-8
1-(4-(2-(6-(1,3-dioxan-2-yl)pyridin-3-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / dimethyl sulfoxide

2: ammonium hydroxide; pyridine / N,N-dimethyl-formamide; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

With pyridine; ammonium hydroxide; potassium tert-butylate; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; dimethyl sulfoxide; N,N-dimethyl-formamide;