phenyl (S)-3,5-dihydroxy-5-methyl-3-phenylhexyl-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)carbamate

Base Information

Chemical Name:phenyl (S)-3,5-dihydroxy-5-methyl-3-phenylhexyl-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)carbamate
CAS No.:1383540-76-8
Molecular Formula:C₃₄H₃₈N₂O₅
Molecular Weight:554.686
Hs Code.:

Synonyms:phenyl (S)-3,5-dihydroxy-5-methyl-3-phenylhexyl-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)carbamate

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Chemical Property of phenyl (S)-3,5-dihydroxy-5-methyl-3-phenylhexyl-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)carbamate

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Technology Process of phenyl (S)-3,5-dihydroxy-5-methyl-3-phenylhexyl-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)carbamate

There total 5 articles about phenyl (S)-3,5-dihydroxy-5-methyl-3-phenylhexyl-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.8%

: 1383540-77-9
(S)-4-(4-(1-aminoethyl)phenyl)-1-methylpyridin-2(1H)-one

: 1383540-75-7
(R)-3-hydroxy-5-methyl-3-phenyl-5-(trimethylsilyloxy)hexanal

: 1885-14-9
phenyl chloroformate

: 1383540-76-8
phenyl (S)-3,5-dihydroxy-5-methyl-3-phenylhexyl-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)carbamate

Guidance literature:: (S)-4-(4-(1-aminoethyl)phenyl)-1-methylpyridin-2(1H)-one; (R)-3-hydroxy-5-methyl-3-phenyl-5-(trimethylsilyloxy)hexanal; With sodium tetrahydroborate; In methanol; at 25 ℃; for 15h;

phenyl chloroformate; With potassium carbonate; In methanol; at 25 ℃; for 1h;

With water; In methanol; at 25 ℃; for 2.5h;

Reference yield:

: 98-86-2
acetophenone

: 1383540-76-8
phenyl (S)-3,5-dihydroxy-5-methyl-3-phenylhexyl-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / -50 °C

1.2: -50 °C

1.3: -50 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 25 - 35 °C

3.1: (R)-3,3'-dibromo-1,1'-bi-2-naphthol / tert-butyl alcohol / 24 h / 23 °C / Inert atmosphere

4.1: ozone / dichloromethane; methanol / -78 - -70 °C

5.1: sodium tetrahydroborate / methanol / 15 h / 25 °C

5.2: 1 h / 25 °C

5.3: 2.5 h / 25 °C

With 1H-imidazole; sodium tetrahydroborate; ozone; lithium diisopropyl amide; (R)-3,3'-dibromo-1,1'-bi-2-naphthol; In tetrahydrofuran; methanol; n-heptane; dichloromethane; ethylbenzene; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 43108-74-3
3-hydroxy-3-methyl-1-phenyl-1-butanone

: 1383540-76-8
phenyl (S)-3,5-dihydroxy-5-methyl-3-phenylhexyl-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 25 - 35 °C

2.1: (R)-3,3'-dibromo-1,1'-bi-2-naphthol / tert-butyl alcohol / 24 h / 23 °C / Inert atmosphere

3.1: ozone / dichloromethane; methanol / -78 - -70 °C

4.1: sodium tetrahydroborate / methanol / 15 h / 25 °C

4.2: 1 h / 25 °C

4.3: 2.5 h / 25 °C

With 1H-imidazole; sodium tetrahydroborate; ozone; (R)-3,3'-dibromo-1,1'-bi-2-naphthol; In methanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;