1-methyl-3-cyclohexenylzinc chloride

Base Information

• Chemical Name: 1-methyl-3-cyclohexenylzinc chloride
• CAS No.: 938446-30-1
• Molecular Formula: C₇H₁₁ClZn
• Molecular Weight: 196.007
• Mol file: 938446-30-1.mol

Synonyms:1-methyl-3-cyclohexenylzinc chloride

Chemical Property of 1-methyl-3-cyclohexenylzinc chloride

Chemical Property:

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Technology Process of 1-methyl-3-cyclohexenylzinc chloride

There total 1 articles about 1-methyl-3-cyclohexenylzinc chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

3-chloro-1-methylcyclohex-1-ene (109458-85-7) + zinc (7440-66-6) → 1-methyl-3-cyclohexenylzinc chloride (938446-30-1)

Guidance literature:

With lithium chloride; In tetrahydrofuran; dropwise addn. of alkenyl chloride to a suspn. of Zn and LiCl in THF, reacting at 0°C for 36 h;

DOI:10.1021/ja071380s

Reference yield: 99.0%

1-methyl-3-cyclohexenylzinc chloride (938446-30-1) + para-bromoacetophenone (99-90-1) → (1SR)-(4-bromophenyl)-1-{(1RS)-1-methylcyclohex-2-enyl}ethanol

Guidance literature:

In tetrahydrofuran; at -78 ℃;

DOI:10.1021/ja071380s

Reference yield: 90.0%

1-methyl-3-cyclohexenylzinc chloride (938446-30-1) + (S)-(-)-N-[1-(p-bromophenyl)ethylidene]-tert-butanesulfinamide → (S)-2-methyl-propane-2-sulfinic acid [(S)-1-(4-bromo-phenyl)-1-((S)-1-methylcyclohex-2-enyl)ethyl]amide (1039750-77-0)

Guidance literature:

In tetrahydrofuran; at -78 - -30 ℃; for 8h; Inert atmosphere;

DOI:10.1021/ol800998u

upstream raw materials:

3-chloro-1-methylcyclohex-1-ene

zinc

Downstream raw materials:

(S)-2-methyl-propane-2-sulfinic acid [(S)-1-(4-bromo-phenyl)-1-((S)-1-methylcyclohex-2-enyl)ethyl]amide