5,6-bis-(3-fluoro-4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole

Base Information

Chemical Name:5,6-bis-(3-fluoro-4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole
CAS No.:66659-74-3
Molecular Formula:C₁₉H₁₆F₂N₂O₂S
Molecular Weight:374.411
Hs Code.:

5,6-bis-(3-fluoro-4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-<i>b</i>]thiazole

Synonyms:5,6-bis-(3-fluoro-4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5,6-bis-(3-fluoro-4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole

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Technology Process of 5,6-bis-(3-fluoro-4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole

There total 5 articles about 5,6-bis-(3-fluoro-4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1779-81-3
4,5-Dihydro-thiazol-2-ylamin

: 2-Bromo-1,2-bis-(3-fluoro-4-methoxy-phenyl)-ethanone

: 66659-74-3
5,6-bis-(3-fluoro-4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole

Guidance literature:: With potassium carbonate; In acetonitrile; for 18h; Ambient temperature;
DOI:10.1021/jm00147a008

Reference yield:

: 351-54-2
3-fluoro-p-anisaldehyde

: 66659-74-3
5,6-bis-(3-fluoro-4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / KCN / ethanol; H₂O / 6 h / Heating

2: 60 percent / Sn, CuSO₄, aq. conc. HCl / ethanol / 9 h / Heating

3: Br₂ / CCl₄ / 1 h / Ambient temperature

4: 57 percent / K₂CO₃ / acetonitrile / 18 h / Ambient temperature

With hydrogenchloride; potassium cyanide; tin; bromine; potassium carbonate; copper(II) sulfate; In tetrachloromethane; ethanol; water; acetonitrile;
DOI:10.1021/jm00147a008

Reference yield:

: 1827-54-9
bis(3-fluoro-4-methoxy)desoxybenzoin

: 66659-74-3
5,6-bis-(3-fluoro-4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: Br₂ / CCl₄ / 1 h / Ambient temperature

2: 57 percent / K₂CO₃ / acetonitrile / 18 h / Ambient temperature

With bromine; potassium carbonate; In tetrachloromethane; acetonitrile;
DOI:10.1021/jm00147a008