Technology Process of 2-(4'-chloro-biphenyl-3-yl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester
There total 5 articles about 2-(4'-chloro-biphenyl-3-yl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; water;
at 110 ℃;
for 1h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ethanol / 2 h / Reflux
2: water / ytterbium(III) trifluoromethanesulfonate hydrate / tetrahydrofuran / 5 h / 25 °C
3: trifluoroacetic acid; triethylsilane / 4 h / 25 °C
4: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1 h / 110 °C / Microwave irradiation
With
triethylsilane; water; sodium carbonate; trifluoroacetic acid;
tetrakis(triphenylphosphine) palladium(0); ytterbium(III) trifluoromethanesulfonate hydrate;
In
tetrahydrofuran; 1,4-dioxane; ethanol; water;
2: Diels-Alder Reaction / 4: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ethanol / 2 h / Reflux
2: water / ytterbium(III) trifluoromethanesulfonate hydrate / tetrahydrofuran / 5 h / 25 °C
3: trifluoroacetic acid; triethylsilane / 4 h / 25 °C
4: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1 h / 110 °C / Microwave irradiation
With
triethylsilane; water; sodium carbonate; trifluoroacetic acid;
tetrakis(triphenylphosphine) palladium(0); ytterbium(III) trifluoromethanesulfonate hydrate;
In
tetrahydrofuran; 1,4-dioxane; ethanol; water;
2: Diels-Alder Reaction / 4: Suzuki Coupling;