[5-chloro-2-(2,2-dimethylpropylamino)phenyl]-(2,3-dimethoxyphenyl)methanol

Base Information

Chemical Name:[5-chloro-2-(2,2-dimethylpropylamino)phenyl]-(2,3-dimethoxyphenyl)methanol
CAS No.:152911-75-6
Molecular Formula:C₂₀H₂₆ClNO₃
Molecular Weight:363.884
Hs Code.:

Synonyms:[5-chloro-2-(2,2-dimethylpropylamino)phenyl]-(2,3-dimethoxyphenyl)methanol

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Chemical Property of [5-chloro-2-(2,2-dimethylpropylamino)phenyl]-(2,3-dimethoxyphenyl)methanol

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Technology Process of [5-chloro-2-(2,2-dimethylpropylamino)phenyl]-(2,3-dimethoxyphenyl)methanol

There total 9 articles about [5-chloro-2-(2,2-dimethylpropylamino)phenyl]-(2,3-dimethoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 630-19-3
pivalaldehyde

: 152911-54-1
(+/-)-2-amino-5-chloro-α-(2,3-dimethoxyphenyl)benzyl alcohol

: 152911-75-6
[5-chloro-2-(2,2-dimethylpropylamino)phenyl]-(2,3-dimethoxyphenyl)methanol

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 1h;
DOI:10.1016/S0968-0896(01)00290-5

Reference yield:

: 177410-73-0
(+/-)-5-chloro-α-(2,3-dimethoxyphenyl)-2-pivaloylaminobenzyl alcohol

: 152911-75-6
[5-chloro-2-(2,2-dimethylpropylamino)phenyl]-(2,3-dimethoxyphenyl)methanol

Guidance literature:: (+/-)-5-chloro-α-(2,3-dimethoxyphenyl)-2-pivaloylaminobenzyl alcohol; With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 2h;

With rochelle salt; In tetrahydrofuran; toluene; for 0.0833333h; Saturated solution;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 7033-50-3
6-chloro-2-methyl-4H-benzo[d][1,3]oxazin-4-one

: 152911-75-6
[5-chloro-2-(2,2-dimethylpropylamino)phenyl]-(2,3-dimethoxyphenyl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h

1.2: 37 percent / tetrahydrofuran; hexane / 0.5 h / 0 °C

2.1: 87 percent / NaBH₄ / ethanol / 4 h

3.1: 100 percent / NaBH₃CN; AcOH / methanol / 1 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; ethanol; hexane;
DOI:10.1016/S0968-0896(01)00290-5