4-Methoxy-2-methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester

Base Information

• Chemical Name: 4-Methoxy-2-methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester
• CAS No.: 121507-77-5
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.294
• Mol file: 121507-77-5.mol

Synonyms:4-Methoxy-2-methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester

Chemical Property of 4-Methoxy-2-methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methoxy-2-methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester

There total 4 articles about 4-Methoxy-2-methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-Hydroxy-2-methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester (121507-76-4) + methyl iodide (74-88-4) → 4-Methoxy-2-methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester (121507-77-5)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 1h; -78 deg C to room temp.;

DOI:10.1016/S0040-4039(00)82435-1

Reference yield:

4-methoxypyridine (620-08-6,1232006-56-2) → 4-Methoxy-2-methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester (121507-77-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / tetrahydrofuran

2: NaBH₄/CeCl₃

3: 73 percent / t-BuOK / tetrahydrofuran / 1 h / -78 deg C to room temp.

With sodium tetrahydroborate; cerium(III) chloride; potassium tert-butylate; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)82435-1

Reference yield:

N-(phenoxycarbonyl)-2-methyl-2,3-dihydropyrid-4-one (107971-38-0) → 4-Methoxy-2-methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester (121507-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄/CeCl₃

2: 73 percent / t-BuOK / tetrahydrofuran / 1 h / -78 deg C to room temp.

With sodium tetrahydroborate; cerium(III) chloride; potassium tert-butylate; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)82435-1

upstream raw materials:

4-Hydroxy-2-methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester

methyl iodide

4-methoxypyridine

N-(phenoxycarbonyl)-2-methyl-2,3-dihydropyrid-4-one

Downstream raw materials:

2,6-trans-6-methyl-1-phenoxycarbonyl-2-propyl-1,2,5,6-tetrahydro-pyridine

2,6-cis-6-methyl-1-phenoxycarbonyl-2-propyl-1,2,5,6-tetrahydro-pyridine