107971-38-0Relevant articles and documents
Synthesis and structure - Activity relationship studies of novel dihydropyridones as androgen receptor modulators
Pepe, Antonella,Pamment, Michae,Kim, Yeong Sang,Lee, Sunmin,Lee, Min-Jung,Beebe, Kristin,Filikov, Anton,Neckers, Len,Trepel, Jane B.,Malhotra, Sanjay V.
, p. 8280 - 8297 (2013)
A library of 3-hydroxy-2,3-dihydropyridones was synthesized, and their activities as antiandrogens were tested in the human prostate cancer cell line LNCaP. Structure-activity relationship (SAR) studies resulted in the identification of a potent compound
C-3 acetoxylation of N-acyl-2,3-dihydro-4-pyridones
Comins, Daniel L.,Stolze, David A.,Thakker, Paresh,McArdle, Cheryl L.
, p. 5693 - 5696 (2007/10/03)
Stereoselective acetoxylation at the C-3 position of N-acyl-2-alkyl- 2,3-dihydro-4-pyridones was effected with Pb(OAc)4 in refluxing toluene.
THE ADDITION OF ALKYLZINC IODIDES TO 1-(PHENOXYCARBONYL)-2,3-DIHYDROPYRIDINIUM SALTS. A SYNTHESIS OF 2-ALKYL-Δ3-PIPERIDINES.
Comins, Daniel L.,Foley, Michael A.
, p. 6711 - 6714 (2007/10/02)
Several 2-alkyl-1-(phenoxycarbonyl)-Δ3-piperidines were prepared by the addition of alkylzinc iodides to 1-(phenoxycarbonyl)-2,3-dihydropyridinium salts.