diphenyl(2,2,6,6-tetramethylpiperidin-1-yl)phosphine oxide

Base Information

• Chemical Name: diphenyl(2,2,6,6-tetramethylpiperidin-1-yl)phosphine oxide
• CAS No.: 1207173-53-2
• Molecular Formula: C₂₁H₂₈NOP
• Molecular Weight: 341.433
• Mol file: 1207173-53-2.mol

Synonyms:diphenyl(2,2,6,6-tetramethylpiperidin-1-yl)phosphine oxide

Chemical Property of diphenyl(2,2,6,6-tetramethylpiperidin-1-yl)phosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of diphenyl(2,2,6,6-tetramethylpiperidin-1-yl)phosphine oxide

There total 3 articles about diphenyl(2,2,6,6-tetramethylpiperidin-1-yl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

N-propargylbenzylamine (1197-51-9) + 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) + carbon dioxide (124-38-9,18923-20-1) + Diphenylphosphine oxide (4559-70-0) → 5-methylene-3-(phenylmethyl)-2-oxazolidinone (92288-02-3) + diphenyl(2,2,6,6-tetramethylpiperidin-1-yl)phosphine oxide (1207173-53-2) + 3-benzyl-5-((diphenylphosphoryl)methyl)oxazolidin-2-one

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; copper diacetate; In water; N,N-dimethyl-formamide; at 20 - 60 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.0c02172

Reference yield:

C21H28NP → diphenyl(2,2,6,6-tetramethylpiperidin-1-yl)phosphine oxide (1207173-53-2)

Guidance literature:

With dihydrogen peroxide; In tetrahydrofuran; hexane; water; at -20 ℃; Inert atmosphere;

DOI:10.1021/ol902545q

Reference yield:

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) + diphenylphosphane (829-85-6) → diphenyl(2,2,6,6-tetramethylpiperidin-1-yl)phosphine oxide (1207173-53-2) + 2,2,6,6-tetramethylpiperidin-1-yl diphenylphosphinate (112537-94-7) + Diphenylphosphine oxide (4559-70-0)

Guidance literature:

In tetrahydrofuran-d8; at -15 ℃;

DOI:10.1002/chem.201504900

upstream raw materials:

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

diphenylphosphane

N-propargylbenzylamine

carbon dioxide