3-(4-(5-amino-6-(pyridin-3-ylcarbamoyl)pyrazin-2-yl)phenyl)propyl methanesulfonate

Base Information

Chemical Name:3-(4-(5-amino-6-(pyridin-3-ylcarbamoyl)pyrazin-2-yl)phenyl)propyl methanesulfonate
CAS No.:1318792-79-8
Molecular Formula:C₂₀H₂₁N₅O₄S
Molecular Weight:427.484
Hs Code.:

Synonyms:3-(4-(5-amino-6-(pyridin-3-ylcarbamoyl)pyrazin-2-yl)phenyl)propyl methanesulfonate

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Chemical Property of 3-(4-(5-amino-6-(pyridin-3-ylcarbamoyl)pyrazin-2-yl)phenyl)propyl methanesulfonate

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Technology Process of 3-(4-(5-amino-6-(pyridin-3-ylcarbamoyl)pyrazin-2-yl)phenyl)propyl methanesulfonate

There total 10 articles about 3-(4-(5-amino-6-(pyridin-3-ylcarbamoyl)pyrazin-2-yl)phenyl)propyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1318792-78-7
3-amino-6-(4-(3-hydroxypropyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide

: 124-63-0
methanesulfonyl chloride

: 1318792-79-8
3-(4-(5-amino-6-(pyridin-3-ylcarbamoyl)pyrazin-2-yl)phenyl)propyl methanesulfonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃; for 2.16667h; Inert atmosphere;

Reference yield:

: 25574-11-2
3-(4-bromophenyl)propanol

: 1318792-79-8
3-(4-(5-amino-6-(pyridin-3-ylcarbamoyl)pyrazin-2-yl)phenyl)propyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; triethylamine / dichloromethane / 17 - 25 °C / Inert atmosphere

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 10 h / 90 °C / Inert atmosphere

4.1: hydrogen fluoride / tetrahydrofuran / 3 h / 17 - 25 °C / Inert atmosphere

4.2: 17 - 25 °C / pH 10 - 11 / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 25 °C / Inert atmosphere

With dmap; hydrogen fluoride; potassium acetate; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 153993-80-7
[3-(4-bromophenyl)propoxy](tert-butyl)dimethylsilane

: 1318792-79-8
3-(4-(5-amino-6-(pyridin-3-ylcarbamoyl)pyrazin-2-yl)phenyl)propyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 10 h / 90 °C / Inert atmosphere

3.1: hydrogen fluoride / tetrahydrofuran / 3 h / 17 - 25 °C / Inert atmosphere

3.2: 17 - 25 °C / pH 10 - 11 / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 25 °C / Inert atmosphere

With hydrogen fluoride; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;