2-cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3-phenylacrylamide

Base Information

• Chemical Name: 2-cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3-phenylacrylamide
• CAS No.: 354769-12-3
• Molecular Formula: C₁₉H₁₅N₃OS
• Molecular Weight: 333.414
• Mol file: 354769-12-3.mol

Synonyms:2-cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3-phenylacrylamide

Chemical Property of 2-cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3-phenylacrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3-phenylacrylamide

There total 2 articles about 2-cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3-phenylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo [b]thiophen-2-yl)acetamide (73227-84-6) + benzaldehyde (100-52-7) → 2-cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3-phenylacrylamide (354769-12-3)

Guidance literature:

With piperidine; In 1,4-dioxane; for 5h; Reflux;

DOI:10.3390/molecules16010052

Reference yield:

3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene (4651-91-6) → 2-cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3-phenylacrylamide (354769-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 5 h / Reflux

2: piperidine / 1,4-dioxane / 5 h / Reflux

With piperidine; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.3390/molecules16010052

Reference yield: 76.0%

2-cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3-phenylacrylamide (354769-12-3) + phenylhydrazine (100-63-0) → C25H21N5S + 3-amino-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1,5-diphenyl-1H-pyrazol-4-yl-carboxamide (1269840-92-7)

Guidance literature:

In 1,4-dioxane; N,N-dimethyl-formamide; for 5h; Reflux;

DOI:10.3390/molecules16010052

upstream raw materials:

3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene

2-cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo [b]thiophen-2-yl)acetamide

benzaldehyde

Downstream raw materials:

3-amino-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-5-phenyl-1H-pyrazol-4-yl-carboxamide

ethyl 2-amino-5-cyano-1-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1,6-dihydro-6-oxo-4-phenylpyridine-3-carboxylate

3-amino-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1,5-diphenyl-1H-pyrazol-4-yl-carboxamide

6-amino-1-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-2-oxo-4-phenylpyridine-3,5-dicarbonitrile