t-Boc-N-amido-PEG9-Amine

Base Information

Chemical Name:t-Boc-N-amido-PEG9-Amine
CAS No.:890091-43-7
Molecular Formula:C25H52 N2 O11
Molecular Weight:556.695
Hs Code.:2924190090
DSSTox Substance ID:DTXSID10405128
Nikkaji Number:J3.192.523A
Wikidata:Q72440175
Mol file:890091-43-7.mol

Synonyms:890091-43-7;t-Boc-N-amido-PEG9-Amine;Boc-amido-PEG9-amine;BocNH-PEG9-CH2CH2NH2;NHBoc-PEG9-amine;O-(2-Aminoethyl)-O'-[2-(Boc-amino)ethyl]octaethylene glycol;BOC-NH-PEG9-NH2;tert-butyl (29-amino-3,6,9,12,15,18,21,24,27-nonaoxanonacosyl)carbamate;Boc-N-amido-PEG9-Amine;Boc-PEG-amine (n=9);Boc-N-amido-PEG9-NH2;Boc-PEG-amine (n=8);tert-butyl N-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate;SCHEMBL21113607;DTXSID10405128;MFCD03453249;O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL;AKOS040741402;O-(2-Aminoethyl)-O inverted exclamation marka-[2-(Boc-amino)ethyl]octaethylene glycol;BP-22604;SY251203;WS-01853;HY-140233;CS-0114311;C70743

Suppliers and Price of t-Boc-N-amido-PEG9-Amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
O-(2-Aminoethyl)-O′-[2-(Boc-amino)ethyl]octaethylene glycol ≥90%(oligomerpurity)
500 mg
$ 440.00

Sigma-Aldrich
O-(2-Aminoethyl)-O′-[2-(Boc-amino)ethyl]octaethylene glycol ≥90% (oligomer purity)
500mg-f
$ 416.00

purepeg
BocNH-PEG9-CH2CH2NH2 min.95%
250 mg
$ 193.00

ChemPep
Boc-NH-PEG9-CH2CH2NH2
1g
$ 495.00

ChemPep
Boc-NH-PEG9-CH2CH2NH2
500mg
$ 275.00

ChemPep
Boc-NH-PEG9-CH2CH2NH2
5g
$ 1450.00

BroadPharm
t-Boc-N-amido-PEG9-amine 98%
5 G
$ 1450.00

BroadPharm
t-Boc-N-amido-PEG10-amine 95%
1 G
$ 1250.00

BroadPharm
t-Boc-N-amido-PEG10-amine 95%
500 MG
$ 750.00

BroadPharm
t-Boc-N-amido-PEG10-amine 95%
250 MG
$ 450.00

Total 27 raw suppliers

Chemical Property of t-Boc-N-amido-PEG9-Amine

Chemical Property:

Vapor Pressure:8.18E-15mmHg at 25°C
Refractive Index:1.465
Boiling Point:609.8oC at 760 mmHg
Flash Point:322.6oC
PSA：150.91000
Density:1.082g/cm3
LogP:1.52390
Storage Temp.:2-8°C
Solubility.:Soluble in Water, DMSO, DMF, DCM
XLogP3:-1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:31
Exact Mass:556.35711048
Heavy Atom Count:38
Complexity:496

Purity/Quality:

98%,99%, ^*data from raw suppliers

O-(2-Aminoethyl)-O′-[2-(Boc-amino)ethyl]octaethylene glycol ≥90%(oligomerpurity) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
Description t-Boc-N-amido-PEG9-amine is a monodisperse PEG reagent containing an amino group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Technology Process of t-Boc-N-amido-PEG9-Amine

There total 9 articles about t-Boc-N-amido-PEG9-Amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 474082-35-4
2-(2-(2-(2-(2-(2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanamine

: 24424-99-5
di-tert-butyl dicarbonate

: 890091-43-7
tert-butyl 2-(2-(2-(2-(2-(2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethylcarbamate

Guidance literature:: In dichloromethane; at 20 ℃; for 14h; Inert atmosphere;
DOI:10.1002/anie.201707536

Reference yield:

: 77544-60-6
p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester

: 890091-43-7
tert-butyl 2-(2-(2-(2-(2-(2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.83 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h / 20 °C / Inert atmosphere; Schlenk technique

3.2: 24 h / 20 °C / Inert atmosphere; Schlenk technique

4.1: hydrogen; palladium 10% on activated carbon / methanol / 0 °C / 760.05 Torr

5.1: dichloromethane / 14 h / 20 °C / Inert atmosphere

With sodium azide; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/anie.201707536

Reference yield:

: 86770-67-4
2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol

: 890091-43-7
tert-butyl 2-(2-(2-(2-(2-(2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.83 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h / 20 °C / Inert atmosphere; Schlenk technique

2.2: 24 h / 20 °C / Inert atmosphere; Schlenk technique

3.1: hydrogen; palladium 10% on activated carbon / methanol / 0 °C / 760.05 Torr

4.1: dichloromethane / 14 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; mineral oil;
DOI:10.1002/anie.201707536