Amino-PEG9-Amine

Base Information

• Chemical Name: Amino-PEG9-Amine
• CAS No.: 474082-35-4
• Molecular Formula: C₂₀H₄₄N₂O₉
• Molecular Weight: 456.577
• Mol file: 474082-35-4.mol

Synonyms:2-(2-(2-(2-(2-(2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanamine

Chemical Property of Amino-PEG9-Amine

Chemical Property:

• Boiling Point: 527.4±45.0 °C(Predicted)
• PKA: 9.04±0.10(Predicted)
• Density: 1.078±0.06 g/cm3(Predicted)

Purity/Quality:

98%,99%, ^*data from raw suppliers

H2N-PEG9-CH2CH2NH2 min.95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Amino-PEG9-Amine is a PEG linker containing two amine functional groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Technology Process of Amino-PEG9-Amine

There total 13 articles about Amino-PEG9-Amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(2-(2-(2-(2-(2-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)-2-azidoethane → 2-(2-(2-(2-(2-(2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanamine (474082-35-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 0 ℃; under 760.051 Torr;

DOI:10.1002/anie.201707536

Reference yield: 61.0%

C36H48N2O15 → 2-(2-(2-(2-(2-(2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanamine (474082-35-4)

Guidance literature:

With hydrazine; In methanol; for 4.5h; Heating;

DOI:10.1021/ja026895s

Reference yield:

pentaethylene glycol (2615-15-8) → 2-(2-(2-(2-(2-(2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanamine (474082-35-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 42 percent / pyridine / 74 h / -20 °C

2.1: NaH / tetrahydrofuran / 0.17 h / 50 °C

2.2: 55 percent / tetrahydrofuran / 5 h / 80 °C

3.1: 43 percent / water / p-toluene sulfonic acid monohydrate / CH₂Cl₂; methanol / 10 h / 20 °C

4.1: 86 percent / triethylamine / tetrahydrofuran / 0 - 20 °C

5.1: 75 percent / dimethylformamide / 3 h / 120 °C

6.1: 61 percent / hydrazine / methanol / 4.5 h / Heating

With pyridine; water; sodium hydride; triethylamine; hydrazine; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja026895s

upstream raw materials:

decaethylene glycol dimesylate

2-{2-[2-(2-{2-[2-(2-{2-[2-(2-trityloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethanol

pentaethylene glycol

decaethylene glycol

Downstream raw materials:

tert-butyl 2-(2-(2-(2-(2-(2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethylcarbamate

Refernces

• 1、 -. "BIFUNCTIONAL ANTIFUNGAL AGENTS AND METHODS OF TREATING FUNGAL INFECTION". . . Retrieved 2018/03/09.
• 2、 Bandyopadhyay, Prasun,Bandyopadhyay, Punam,Regen, Steven L.. "An ion conductor that recognizes osmotically-stressed phospholipid bilayers". . p. 11254 - 11255. Retrieved 2007/10/03.