4-(chloro(4-chlorophenyl)methyl)-1,2-di(tert-butoxycarbonylamino)benzene

Base Information

Chemical Name:4-(chloro(4-chlorophenyl)methyl)-1,2-di(tert-butoxycarbonylamino)benzene
CAS No.:1285819-60-4
Molecular Formula:C₂₃H₂₈Cl₂N₂O₄
Molecular Weight:467.392
Hs Code.:

Synonyms:4-(chloro(4-chlorophenyl)methyl)-1,2-di(tert-butoxycarbonylamino)benzene

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Chemical Property of 4-(chloro(4-chlorophenyl)methyl)-1,2-di(tert-butoxycarbonylamino)benzene

Chemical Property:

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Technology Process of 4-(chloro(4-chlorophenyl)methyl)-1,2-di(tert-butoxycarbonylamino)benzene

There total 4 articles about 4-(chloro(4-chlorophenyl)methyl)-1,2-di(tert-butoxycarbonylamino)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1285819-58-0
4'-chloro-3,4-di(tert-butoxycarbonylamino)benzhydrol

: 124-63-0
methanesulfonyl chloride

: 1285819-60-4
4-(chloro(4-chlorophenyl)methyl)-1,2-di(tert-butoxycarbonylamino)benzene

: 1285819-59-1
(3,4-bis(tert-butoxycarbonylamino)phenyl)(4-chlorophenyl)methyl methanesulfonate

Guidance literature:: With triethylamine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2010.12.057

Reference yield:

: 1285819-57-9
4'-chloro-3,4-di(tert-butoxycarbonylamino)benzophenone

: 1285819-60-4
4-(chloro(4-chlorophenyl)methyl)-1,2-di(tert-butoxycarbonylamino)benzene

: 1285819-59-1
(3,4-bis(tert-butoxycarbonylamino)phenyl)(4-chlorophenyl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 0 - 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran; dichloromethane / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmc.2010.12.057

Reference yield:

: 31431-17-1
4,4'-dichloro-3-nitrobenzophenone

: 1285819-60-4
4-(chloro(4-chlorophenyl)methyl)-1,2-di(tert-butoxycarbonylamino)benzene

: 1285819-59-1
(3,4-bis(tert-butoxycarbonylamino)phenyl)(4-chlorophenyl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium azide / N,N-dimethyl-formamide / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 70 °C / Inert atmosphere

4: sodium tetrahydroborate / tetrahydrofuran; ethanol / 0 - 20 °C / Inert atmosphere

5: triethylamine / tetrahydrofuran; dichloromethane / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium azide; palladium 10% on activated carbon; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2010.12.057