Technology Process of (2S,3S)-2-(benzyl(methyl)amino)-3-methylpentanal
There total 6 articles about (2S,3S)-2-(benzyl(methyl)amino)-3-methylpentanal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2S,3 S)-2-[benzyl(methyl)amino]-3-methylpentan-1-ol;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -70 ℃;
for 0.0125h;
With
triethylamine;
In
dichloromethane;
at -65 - -50 ℃;
for 1.08333h;
With
water;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water / 0.5 h / 20 °C
2.1: sodium tetrahydroborate; water / 4 h / 5 - 20 °C
3.1: formic acid / water / 3 h / 90 °C / Inert atmosphere
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 65 °C / Inert atmosphere
5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -70 °C / Inert atmosphere
5.2: 1 h / -70 - -50 °C / Inert atmosphere
With
sodium tetrahydroborate; lithium aluminium tetrahydride; formic acid; oxalyl dichloride; water; dimethyl sulfoxide; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: formic acid / water / 3 h / 90 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 65 °C / Inert atmosphere
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -70 °C / Inert atmosphere
3.2: 1 h / -70 - -50 °C / Inert atmosphere
With
lithium aluminium tetrahydride; formic acid; oxalyl dichloride; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane; water;
