N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycine

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycine
CAS No.:208987-31-9
Molecular Formula:C₄₂H₆₁N₃O₁₇
Molecular Weight:879.956
Hs Code.:

N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycine

Synonyms:N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycine

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Chemical Property of N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycine

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Technology Process of N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycine

There total 6 articles about N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 208987-30-8
N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycine ethyl ester

: 208987-31-9
N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycine

Guidance literature:: With sodium hydroxide; water; In methanol; 1.) 0 deg C, 0.5 h, 2.) r.t., 3 h;

Reference yield:

: 4933-77-1
(3aR,5S,5aR,8aS,8bR)-2,2,7,7-Tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-carbaldehyde

: 208987-31-9
N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycine

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / bromotripyrrolidinophosphonium hexafluorophosphate, NMM / CH₂Cl₂ / 1.) 0 deg C, 5 min, 2.) r.t., overnight

2: 93 percent / H₂O, NaOH / methanol / 1.) 0 deg C, 0.5 h, 2.) r.t., 3 h

With 4-methyl-morpholine; sodium hydroxide; water; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; dichloromethane;

Reference yield:

: 20866-48-2
(S)-2-(tert-butoxycarbonylamino)-3-(4-(tert-butoxycarbonyloxy)phenyl)propanoic acid

: 208987-31-9
N-(tert-butoxycarbonyl)-L-tyrosyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycyl-N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactos-6-yl)glycine

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / BOP, HOBT, NMM, molecular sieves 4 Angstroem / CH₂Cl₂ / 36 h / Ambient temperature

2: 82 percent / NaOH, H₂O / methanol / 1.) 0 deg C, 0.5 h, 2.) r.t., 3 h

3: 94 percent / bromotripyrrolidinophosphonium hexafluorophosphate, NMM / CH₂Cl₂ / 1.) 0 deg C, 5 min, 2.) r.t., overnight

4: 93 percent / H₂O, NaOH / methanol / 1.) 0 deg C, 0.5 h, 2.) r.t., 3 h

With 4-methyl-morpholine; sodium hydroxide; 4 A molecular sieve; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; dichloromethane;