(2-(Piperidin-1-yl)pyridin-4-yl)methanol

Base Information

• Chemical Name: (2-(Piperidin-1-yl)pyridin-4-yl)methanol
• CAS No.: 888070-04-0
• Molecular Formula: C11H16 N2 O
• Molecular Weight: 192.261
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00594595
• Wikidata: Q82489486
• Mol file: 888070-04-0.mol

Synonyms:888070-04-0;(2-piperidinopyrid-4-yl)methanol;(2-(Piperidin-1-yl)pyridin-4-yl)methanol;(2-piperidin-1-ylpyridin-4-yl)methanol;[2-(Piperidin-1-yl)pyridin-4-yl]methanol;SCHEMBL3752158;DTXSID00594595;QAQDFPCLEBLUQJ-UHFFFAOYSA-N;MFCD09025858;AKOS010506366;AS-9247;SB42104;(2-piperidin-1-yl pyridin-4-yl)methanol;(2-piperidin-1-yl pyridin-4-yl) methanol;DB-078226;CS-0322052;A1-01375

Chemical Property of (2-(Piperidin-1-yl)pyridin-4-yl)methanol

Chemical Property:

• Vapor Pressure: 9.52E-07mmHg at 25°C
• Refractive Index: 1.573
• Boiling Point: 389°C at 760 mmHg
• PKA: 13.41±0.10(Predicted)
• Flash Point: 189.1°C
• PSA: 36.36000
• Density: 1.139g/cm³
• LogP: 1.62920
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 192.126263138
• Heavy Atom Count: 14
• Complexity: 169

Purity/Quality:

99%, ^*data from raw suppliers

(2-Piperidin-1-ylpyridin-4-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C2=NC=CC(=C2)CO

Technology Process of (2-(Piperidin-1-yl)pyridin-4-yl)methanol

There total 5 articles about (2-(Piperidin-1-yl)pyridin-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

methyl 2-piperidin-1-ylisonicotinate (888070-05-1) → (2-piperidin-1-yl pyridin-4-yl)methanol (888070-04-0)

Guidance literature:

methyl 2-piperidin-1-ylisonicotinate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

With sodium hydroxide; water; In tetrahydrofuran; at -20 ℃;

Reference yield:

2-bromoisonicotinic acid (66572-56-3) → (2-piperidin-1-yl pyridin-4-yl)methanol (888070-04-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 24 h / 105 °C / Heating / reflux

2.1: thionyl chloride / 20 h / 0 °C / Heating / reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

3.2: -20 °C

With lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran;

Reference yield:

2-Amino-4-methylpyridine (695-34-1) → (2-piperidin-1-yl pyridin-4-yl)methanol (888070-04-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogen bromide; bromine / water / 3 h / -20 - -15 °C

1.2: 3 h / 20 °C

1.3: 0 °C / pH 12

2.1: potassium permanganate / pyridine; water / 96 h / 95 °C

3.1: 24 h / 105 °C / Heating / reflux

4.1: thionyl chloride / 20 h / 0 °C / Heating / reflux

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

5.2: -20 °C

With potassium permanganate; lithium aluminium tetrahydride; thionyl chloride; hydrogen bromide; bromine; In tetrahydrofuran; pyridine; water;

upstream raw materials:

methyl 2-piperidin-1-ylisonicotinate

2-Amino-4-methylpyridine

2-Bromo-4-picoline

2-(piperidin-1-yl)isonicotinic acid

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