(4-benzyloxy-1-iodo-5,6,7,8-tetrahydro-naphthalen-2-yl)-(3-chloro-but-2-enyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(4-benzyloxy-1-iodo-5,6,7,8-tetrahydro-naphthalen-2-yl)-(3-chloro-but-2-enyl)-carbamic acid tert-butyl ester
CAS No.:452921-85-6
Molecular Formula:C₂₆H₃₁ClINO₃
Molecular Weight:567.895
Hs Code.:

(4-benzyloxy-1-iodo-5,6,7,8-tetrahydro-naphthalen-2-yl)-(3-chloro-but-2-enyl)-carbamic acid <i>tert</i>-butyl ester

Synonyms:(4-benzyloxy-1-iodo-5,6,7,8-tetrahydro-naphthalen-2-yl)-(3-chloro-but-2-enyl)-carbamic acid tert-butyl ester

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Chemical Property of (4-benzyloxy-1-iodo-5,6,7,8-tetrahydro-naphthalen-2-yl)-(3-chloro-but-2-enyl)-carbamic acid tert-butyl ester

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Technology Process of (4-benzyloxy-1-iodo-5,6,7,8-tetrahydro-naphthalen-2-yl)-(3-chloro-but-2-enyl)-carbamic acid tert-butyl ester

There total 8 articles about (4-benzyloxy-1-iodo-5,6,7,8-tetrahydro-naphthalen-2-yl)-(3-chloro-but-2-enyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 926-57-8
1,3-dichloro-2-butene

: 452921-69-6
4-benzyloxy-2-(tert-butyloxycarbonylamino)-1-iodo-5,6,7,8-tetrahydronaphthalene

: 452921-85-6
(4-benzyloxy-1-iodo-5,6,7,8-tetrahydro-naphthalen-2-yl)-(3-chloro-but-2-enyl)-carbamic acid tert-butyl ester

Guidance literature:: 4-benzyloxy-2-(tert-butyloxycarbonylamino)-1-iodo-5,6,7,8-tetrahydronaphthalene; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

1,3-dichloro-2-butene; In N,N-dimethyl-formamide; at 20 ℃; for 14h; Further stages.;
DOI:10.1002/1099-0690(200205)2002:10<1634::AID-EJOC1634>3.0.CO;2-Y

Reference yield:

: 119-64-2
tetralin

: 452921-85-6
(4-benzyloxy-1-iodo-5,6,7,8-tetrahydro-naphthalen-2-yl)-(3-chloro-but-2-enyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 16 percent / HNO₃; H₂SO₄

2.1: 27 percent / SnCl₂; HCl; HOAc / ethanol / 5 h

3.1: NaNO₂; H₂SO₄ / H₂O / 1 h / -5 °C

3.2: 54 percent / H₂O / -5 - 60 °C

4.1: 97 percent / K₂CO₃; tetrabutylammonium iodide / acetone; dimethylformamide / 14 h / 20 °C

5.1: 100 percent / H₂ / PtO₂*H₂O / dioxane / 24 h / 2250.23 Torr

6.1: 82 percent / dioxane / 24 h / 20 °C

7.1: 94 percent / I₂; HIO₃ / methanol; H₂O / 1.5 h / 65 °C

8.1: NaH / dimethylformamide / 0.5 h / 20 °C

8.2: 99 percent / dimethylformamide / 14 h / 20 °C

With hydrogenchloride; sulfuric acid; hydrogen; iodine; nitric acid; iodic acid; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; acetic acid; tin(ll) chloride; sodium nitrite; platinum(IV) oxide; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/1099-0690(200205)2002:10<1634::AID-EJOC1634>3.0.CO;2-Y

Reference yield:

: 51522-30-6
5,7-dinitro-1,2,3,4-tetrahydronaphthalene

: 452921-85-6
(4-benzyloxy-1-iodo-5,6,7,8-tetrahydro-naphthalen-2-yl)-(3-chloro-but-2-enyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 27 percent / SnCl₂; HCl; HOAc / ethanol / 5 h

2.1: NaNO₂; H₂SO₄ / H₂O / 1 h / -5 °C

2.2: 54 percent / H₂O / -5 - 60 °C

3.1: 97 percent / K₂CO₃; tetrabutylammonium iodide / acetone; dimethylformamide / 14 h / 20 °C

4.1: 100 percent / H₂ / PtO₂*H₂O / dioxane / 24 h / 2250.23 Torr

5.1: 82 percent / dioxane / 24 h / 20 °C

6.1: 94 percent / I₂; HIO₃ / methanol; H₂O / 1.5 h / 65 °C

7.1: NaH / dimethylformamide / 0.5 h / 20 °C

7.2: 99 percent / dimethylformamide / 14 h / 20 °C

With hydrogenchloride; sulfuric acid; hydrogen; iodine; iodic acid; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; acetic acid; tin(ll) chloride; sodium nitrite; platinum(IV) oxide; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/1099-0690(200205)2002:10<1634::AID-EJOC1634>3.0.CO;2-Y