(3R)-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

Base Information

Chemical Name:(3R)-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate
CAS No.:1541199-43-2
Molecular Formula:C₁₅H₁₇F₆NO₃
Molecular Weight:373.295
Hs Code.:

Synonyms:(3R)-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

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Chemical Property of (3R)-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

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Technology Process of (3R)-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

There total 5 articles about (3R)-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1541198-40-6
rac-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

: 1541199-43-2
(3R)-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

: 1541199-42-1
(3S)-3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Guidance literature:: rac-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate; With potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide; In water; at 20 ℃; for 144h; pH=8.25; Enzymatic reaction;

In tert-butyl methyl ether; water; at 20 ℃; for 0.25h;

Reference yield:

: 1352062-40-8
C₁₀H₇BrF₆O

: 1541199-43-2
(3R)-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: ammonium acetate / ethanol / 7 h / 80 °C

3.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 144 h / 20 °C / pH 8.25 / Enzymatic reaction

3.2: 0.25 h / 20 °C

With potassium dihydrogenphosphate; n-butyllithium; Amano Lipase PS; ammonium acetate; sodium hydroxide; In ethanol; hexane; di-isopropyl ether; water;

Reference yield:

: 154259-25-3
1-[3-bromo-5-(trifluoromethyl)phenyl]ethanone

: 1541199-43-2
(3R)-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

1.2: 3 h / 20 °C

2.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: ammonium acetate / ethanol / 7 h / 80 °C

4.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 144 h / 20 °C / pH 8.25 / Enzymatic reaction

4.2: 0.25 h / 20 °C

With potassium dihydrogenphosphate; n-butyllithium; Amano Lipase PS; ammonium acetate; tetrabutyl ammonium fluoride; sodium hydroxide; In tetrahydrofuran; ethanol; hexane; di-isopropyl ether; water;