rac-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

Base Information

Chemical Name:rac-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate
CAS No.:1541198-40-6
Molecular Formula:C₁₅H₁₇F₆NO₃
Molecular Weight:373.295
Hs Code.:

Synonyms:rac-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

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Chemical Property of rac-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

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Technology Process of rac-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

There total 4 articles about rac-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1071-46-1
hydrogen ethyl malonate

: 1541198-41-7
C₁₁H₈F₆O₂

: 1541198-40-6
rac-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

Guidance literature:: With ammonium acetate; In ethanol; at 80 ℃; for 7h;

Reference yield:

: 154259-25-3
1-[3-bromo-5-(trifluoromethyl)phenyl]ethanone

: 1541198-40-6
rac-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

1.2: 3 h / 20 °C

2.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: ammonium acetate / ethanol / 7 h / 80 °C

With n-butyllithium; ammonium acetate; tetrabutyl ammonium fluoride; In tetrahydrofuran; ethanol; hexane; di-isopropyl ether;

Reference yield:

: 401-84-3
1,3-dibromo-5-(trifluoromethyl)benzene

: 1541198-40-6
rac-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

2.2: 3 h / 20 °C

3.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

4.1: ammonium acetate / ethanol / 7 h / 80 °C

With n-butyllithium; ammonium acetate; tetrabutyl ammonium fluoride; In tetrahydrofuran; ethanol; hexane; di-isopropyl ether;