(3S)-3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Base Information

Chemical Name:(3S)-3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid
CAS No.:1541199-42-1
Molecular Formula:C₁₃H₁₃F₆NO₃
Molecular Weight:345.242
Hs Code.:

Synonyms:(3S)-3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Suppliers and Price of (3S)-3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S)-3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S)-3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

There total 5 articles about (3S)-3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1541198-40-6
rac-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

: 1541199-43-2
(3R)-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate

: 1541199-42-1
(3S)-3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Guidance literature:: rac-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate; With potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide; In water; at 20 ℃; for 144h; pH=8.25; Enzymatic reaction;

In tert-butyl methyl ether; water; at 20 ℃; for 0.25h;

Reference yield:

: 1352062-40-8
C₁₀H₇BrF₆O

: 1541199-42-1
(3S)-3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: ammonium acetate / ethanol / 7 h / 80 °C

3.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 144 h / 20 °C / pH 8.25 / Enzymatic reaction

3.2: 0.25 h / 20 °C

With potassium dihydrogenphosphate; n-butyllithium; Amano Lipase PS; ammonium acetate; sodium hydroxide; In ethanol; hexane; di-isopropyl ether; water;

Reference yield:

: 154259-25-3
1-[3-bromo-5-(trifluoromethyl)phenyl]ethanone

: 1541199-42-1
(3S)-3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

1.2: 3 h / 20 °C

2.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: ammonium acetate / ethanol / 7 h / 80 °C

4.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 144 h / 20 °C / pH 8.25 / Enzymatic reaction

4.2: 0.25 h / 20 °C

With potassium dihydrogenphosphate; n-butyllithium; Amano Lipase PS; ammonium acetate; tetrabutyl ammonium fluoride; sodium hydroxide; In tetrahydrofuran; ethanol; hexane; di-isopropyl ether; water;