154259-25-3

Usage

Uses

Used in Pharmaceutical Industry:
3'-BroMo-5'-(trifluoroMethyl)acetophenone, 97% is used as a reactant for the preparation of 2-aminothiazole derivatives, which serve as muscarinic M3 receptor positive allosteric modulators. These modulators have potential applications in the treatment of various conditions, such as overactive bladder, chronic obstructive pulmonary disease (COPD), and certain cognitive disorders.

Upstream product

• 958258-15-6 3-bromo-5-(trifluoromethyl)benzoyl chloride 
• 108-59-8 malonic acid dimethyl ester 
• 401-84-3 1,3-dibromo-5-(trifluoromethyl)benzene 
• 78191-00-1 N-Methoxy-N-methylacetamide 
• 328-67-6 3-bromo-5-(trifluoromethyl)benzoic acid 
• 880652-44-8 3-bromo-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide 
• 75-16-1 methylmagnesium bromide 
• 954124-06-2 1-[3-bromo-5-(trifluoromethyl)phenyl]ethanol 
• 477535-41-4 3-bromo-5-(trifluoromethyl)benzaldehyde 
• 107-29-9 Acetaldehyde oxime 
• 54962-75-3 [3-bromo-5-(trifluoromethyl)phenyl]amine 

Downstream Products

• 1403387-49-4 2-(3-(tert-butyl)-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1369932-75-1 1-bromo-3-(tert-butyl)-5-(trifluoromethyl)benzene 
• 1560549-82-7 C₁₉H₂₁F₃O₃ 
• 1541198-41-7 C₁₁H₈F₆O₂ 
• 1541198-40-6 rac-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate 
• 1541199-43-2 (3R)-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate 
• 1541199-42-1 (3S)-3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid 
• 1541199-41-0 (3S)-ethyl 3-amino-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate hydrochloride 
• 1541199-45-4 (3S)-ethyl 3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate 
• 1541197-41-4 (3S)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 954124-24-4 (R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethanol 
• 954124-13-1 (S)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethanol 
• 954124-06-2 1-[3-bromo-5-(trifluoromethyl)phenyl]ethanol 

Relevant academic research and scientific papers

PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS

Compounds of formula I (Formula I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.

PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS

Compounds of formula I (l) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.

2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF

To provide a compound useful as an active ingredient of a pharmacological composition for the treatment of urinary storage symptoms, dysuria, lower urinary tract diseases, and the like. [Solution] The inventors perfected the present invention after discov

BETA AMINO ACID DERIVATIVES AS INTEGRIN ANTAGONISTS

Disclosed herein are novel pharmaceutical agents which are useful as integrin receptor antagonists that mediate the pathologic processes of angiogenesis and fibrosis and as such are useful in pharmaceutical compositions and in methods for treating conditions mediated by these integrins by inhibiting or antagonizing these integrins. The novel pharmaceutical agents include those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods and intermediates useful for making the pharmaceutical agents and methods of using the pharmaceutical agents are also provided.

DERIVATIVES OF N-ACYL-N'-PHENYLPIPERAZINE USEFUL (INTER ALIA) FOR THE PROPHYLAXIS OR TREATMENT OF DIABETES

The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease or condition mediated by an increase in RBP4.

PYRROLO SULFONAMIDE COMPOUNDS FOR MODULATION OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORGAMMA, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES

The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administrating these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo sulfonamide compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.

NK-1 AND SEROTONIN TRANSPORTER INHIBITORS

The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating disorders associated with an excess or imbalance of tachykinins or serotonin or both.