dibenzyl N-benzyloxycarbonyl-glycyl-L-4-thia-5,5-dimethylprolyl-L-glutamate

Base Information

Chemical Name:dibenzyl N-benzyloxycarbonyl-glycyl-L-4-thia-5,5-dimethylprolyl-L-glutamate
CAS No.:869002-32-4
Molecular Formula:C₃₅H₃₉N₃O₈S
Molecular Weight:661.776
Hs Code.:

Synonyms:dibenzyl N-benzyloxycarbonyl-glycyl-L-4-thia-5,5-dimethylprolyl-L-glutamate

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Chemical Property of dibenzyl N-benzyloxycarbonyl-glycyl-L-4-thia-5,5-dimethylprolyl-L-glutamate

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Technology Process of dibenzyl N-benzyloxycarbonyl-glycyl-L-4-thia-5,5-dimethylprolyl-L-glutamate

There total 3 articles about dibenzyl N-benzyloxycarbonyl-glycyl-L-4-thia-5,5-dimethylprolyl-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 869002-29-9
N-benzyloxycarbonylglycyl-L-4-thia-5,5-dimethylproline

: 2791-84-6,227205-81-4
L-glutamic acid dibenzyl ester 4-toluenesulfonate

: 869002-32-4
dibenzyl N-benzyloxycarbonyl-glycyl-L-4-thia-5,5-dimethylprolyl-L-glutamate

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 7h;
DOI:10.1016/j.tet.2005.08.026

Reference yield:

: 133010-18-1
Z-glycine fluoride

: 869002-32-4
dibenzyl N-benzyloxycarbonyl-glycyl-L-4-thia-5,5-dimethylprolyl-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylethylamine / dimethylformamide / 18 h / 20 °C

1.2: 65 percent / trimethylsilyl chloride / 15 h / 20 °C

2.1: 68 percent / diisopropylethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 7 h / 20 °C

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.08.026

Reference yield:

: 67089-92-3
L-(-)-2,2-dimethylthiazolidine-4-carboxylic acid hydrochloride salt

: 869002-32-4
dibenzyl N-benzyloxycarbonyl-glycyl-L-4-thia-5,5-dimethylprolyl-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylethylamine / dimethylformamide / 18 h / 20 °C

1.2: 65 percent / trimethylsilyl chloride / 15 h / 20 °C

2.1: 68 percent / diisopropylethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 7 h / 20 °C

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.08.026