(R)-2,2-DIMETHYL 4-THIAZOLIDINECARBOXYLIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: (R)-2,2-DIMETHYL 4-THIAZOLIDINECARBOXYLIC ACID HYDROCHLORIDE
• CAS No.: 67089-92-3
• Molecular Formula: C6H12ClNO2S
• Molecular Weight: 197.686
• Hs Code.: 2934999090
• Mol file: 67089-92-3.mol

Synonyms:(R)-2,2-DIMETHYL 4-THIAZOLIDINECARBOXYLIC ACID HYDROCHLORIDE;L-2,2-DIMETHYLTHIAZOLIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE

Chemical Property of (R)-2,2-DIMETHYL 4-THIAZOLIDINECARBOXYLIC ACID HYDROCHLORIDE

Chemical Property:

• PSA: 74.63000
• LogP: 1.64290
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Dimethylsulfoxide, Water

Purity/Quality:

99% ^*data from raw suppliers

L-2,2-Dimethylthiazolidine-4-carboxylic Acid Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-2,2-Dimethylthiazolidine-4-carboxylic Acid Hydrochloride is a chiral thiazolidine used in the preparation of cysteine-derived diketopiperazines and pseudoproline-containing analogs of insect kinin core pentapeptide.

Technology Process of (R)-2,2-DIMETHYL 4-THIAZOLIDINECARBOXYLIC ACID HYDROCHLORIDE

There total 2 articles about (R)-2,2-DIMETHYL 4-THIAZOLIDINECARBOXYLIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

l-cysteine hydrochloride (52-89-1) + acetone (67-64-1) → L-(-)-2,2-dimethylthiazolidine-4-carboxylic acid hydrochloride salt (67089-92-3)

Guidance literature:

for 1.5h; Heating;

DOI:10.1021/jo00276a026

Reference yield: 87.0%

l-cysteine hydrochloride (52-89-1) + 2,2-dimethoxy-propane (77-76-9) → L-(-)-2,2-dimethylthiazolidine-4-carboxylic acid hydrochloride salt (67089-92-3)

Guidance literature:

In acetone; for 6h; Heating;

DOI:10.1016/j.tet.2006.09.009

Reference yield: 86.0%

L-(-)-2,2-dimethylthiazolidine-4-carboxylic acid hydrochloride salt (67089-92-3) + benzoyl chloride (98-88-4) → 3-benzoyl-2,2-dimethylthiazolidine-4R-carboxylic acid (57704-00-4)

Guidance literature:

With pyridine;

DOI:10.3987/COM-09-S(S)101

upstream raw materials:

l-cysteine hydrochloride

acetone

2,2-dimethoxy-propane

Downstream raw materials:

3-benzoyl-2,2-dimethylthiazolidine-4R-carboxylic acid

N-benzyloxycarbonylglycyl-L-4-thia-5,5-dimethylproline

methyl N-benzyloxycarbonylglycinate

N-(Benzyloxycarbonyl)glycine