1-(3-(tert-Butyloxycarbonyl)-2,2-dimethyl-4(S)-cyclohexylmethyl-5(S)-oxazolidinyl)-2(S)-((dimethylaminoethoxycarbonyl)amino)-3-methylbutane

Base Information

Chemical Name:1-(3-(tert-Butyloxycarbonyl)-2,2-dimethyl-4(S)-cyclohexylmethyl-5(S)-oxazolidinyl)-2(S)-((dimethylaminoethoxycarbonyl)amino)-3-methylbutane
CAS No.:130317-39-4
Molecular Formula:C₂₇H₅₁N₃O₅
Molecular Weight:497.719
Hs Code.:

Synonyms:1-(3-(tert-Butyloxycarbonyl)-2,2-dimethyl-4(S)-cyclohexylmethyl-5(S)-oxazolidinyl)-2(S)-((dimethylaminoethoxycarbonyl)amino)-3-methylbutane

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Chemical Property of 1-(3-(tert-Butyloxycarbonyl)-2,2-dimethyl-4(S)-cyclohexylmethyl-5(S)-oxazolidinyl)-2(S)-((dimethylaminoethoxycarbonyl)amino)-3-methylbutane

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Technology Process of 1-(3-(tert-Butyloxycarbonyl)-2,2-dimethyl-4(S)-cyclohexylmethyl-5(S)-oxazolidinyl)-2(S)-((dimethylaminoethoxycarbonyl)amino)-3-methylbutane

There total 2 articles about 1-(3-(tert-Butyloxycarbonyl)-2,2-dimethyl-4(S)-cyclohexylmethyl-5(S)-oxazolidinyl)-2(S)-((dimethylaminoethoxycarbonyl)amino)-3-methylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 2(S)-((3-(tert-butyloxycarbonyl-2,2-dimethyl-4(S)-cyclohexylmethyl-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

: 4129-17-3
diphenylphosphoranyl azide

: 130317-39-4
1-(3-(tert-Butyloxycarbonyl)-2,2-dimethyl-4(S)-cyclohexylmethyl-5(S)-oxazolidinyl)-2(S)-((dimethylaminoethoxycarbonyl)amino)-3-methylbutane

Guidance literature:: With hydrogenchloride; triethylamine; In water; ethyl acetate; toluene;

Reference yield:

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 129921-93-3
2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

: 130317-39-4
1-(3-(tert-Butyloxycarbonyl)-2,2-dimethyl-4(S)-cyclohexylmethyl-5(S)-oxazolidinyl)-2(S)-((dimethylaminoethoxycarbonyl)amino)-3-methylbutane

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; Yield given. Multistep reaction; 1.) toluene, 70 deg C, 1.5 h, 2.) toluene, reflux, 72 h;
DOI:10.1021/jm00088a007

Reference yield:

: 130317-39-4
1-(3-(tert-Butyloxycarbonyl)-2,2-dimethyl-4(S)-cyclohexylmethyl-5(S)-oxazolidinyl)-2(S)-((dimethylaminoethoxycarbonyl)amino)-3-methylbutane

: 140660-82-8
{(1S,3S,4S)-4-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-5-cyclohexyl-3-hydroxy-1-isopropyl-pentyl}-carbamic acid 2-dimethylamino-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: TFA / 1.) CH₂Cl₂, 0 deg C, 3.5 h, 2.a.) THF, H₂O, 0 deg C, 4 h, b.) THF, H₂O, RT, 12 h

2: 2.) HOAc / 1 a.) CH₂Cl₂, 0 deg C, 6 h, b.) RT, 14 h, 2.) THF, water, 50 deg C, 5 h

3: TFA / CH₂Cl₂ / 4 h / 0 °C

4: dimethylformamide / 18 h / Ambient temperature

With acetic acid; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a007