2-methylphenyl 4-fluorobenzenesulfonate

Base Information

• Chemical Name: 2-methylphenyl 4-fluorobenzenesulfonate
• CAS No.: 161912-33-0
• Molecular Formula: C₁₃H₁₁FO₃S
• Molecular Weight: 266.293
• Mol file: 161912-33-0.mol

Synonyms:2-methylphenyl 4-fluorobenzenesulfonate

Chemical Property of 2-methylphenyl 4-fluorobenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methylphenyl 4-fluorobenzenesulfonate

There total 1 articles about 2-methylphenyl 4-fluorobenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-Fluorobenzenesulfonyl chloride (349-88-2) + ortho-cresol (95-48-7,77504-84-8) → 2-methylphenyl 4-fluorobenzenesulfonate (161912-33-0)

Guidance literature:

With pyridine;

DOI:10.1021/jo00106a031

Reference yield: 90.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + 2-methylphenyl 4-fluorobenzenesulfonate (161912-33-0) → ethyl 2-methylbenzoate (87-24-1)

Guidance literature:

With Josiphos Et₂P-Fc-PtBu₂ ligand; sodium acetate; palladium diacetate; at 130 - 135 ℃; for 20h; under 2068.59 Torr;

DOI:10.1021/ol062208g

Reference yield:

2-methylphenyl 4-fluorobenzenesulfonate (161912-33-0) → 2,2'-dimethyl-1,1'-biphenyl (605-39-0)

Guidance literature:

bis(triphenylphosphine)nickel(II) chloride; tetraethylammonium iodide; zinc; In tetrahydrofuran; 1.) r.t., 5 min, 2.) 67 deg C, 5 h;

DOI:10.1021/jo00106a031

upstream raw materials:

4-Fluorobenzenesulfonyl chloride

ortho-cresol

Downstream raw materials:

2,2'-dimethyl-1,1'-biphenyl

ethyl 2-methylbenzoate

Refernces

• 1、 Percec, Virgil,Bae, Jin-Young,Zhao, Mingyang,Hill, Dale H.. "Aryl Mesylates in Metal-Catalyzed Homocoupling and Cross-Coupling Reactions. 1. Functional Symmetrical Biaryls from Phenols via Nickel-Catalyzed Homocoupling of Their Mesylates". . p. 176 - 185. Retrieved 2007/10/02.