N-phthalyl (R,R)-phenylglycine pantolactonyl ester

Base Information

Chemical Name:N-phthalyl (R,R)-phenylglycine pantolactonyl ester
CAS No.:174536-94-8
Molecular Formula:C₂₂H₁₉NO₆
Molecular Weight:393.396
Hs Code.:

Synonyms:N-phthalyl (R,R)-phenylglycine pantolactonyl ester

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Chemical Property of N-phthalyl (R,R)-phenylglycine pantolactonyl ester

Chemical Property:

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Technology Process of N-phthalyl (R,R)-phenylglycine pantolactonyl ester

There total 3 articles about N-phthalyl (R,R)-phenylglycine pantolactonyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5688-96-0
N-phthalyl phenylglycine acid chloride

: 599-04-2
(R)-Pantolacton

: 174536-94-8
N-phthalyl (R,R)-phenylglycine pantolactonyl ester

: (S)-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-phenyl-acetic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Guidance literature:: With triethylamine; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 6 h;
DOI:10.1016/S0957-4166(97)00143-2

Reference yield:

: 4695-37-8
N-phthaloyl-DL-2-phenylglycine

: 174536-94-8
N-phthalyl (R,R)-phenylglycine pantolactonyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride / 12 h / 30 °C

2: Et₃N / tetrahydrofuran / 20 °C

With oxalyl dichloride; triethylamine; In tetrahydrofuran;
DOI:10.1016/S0957-4166(97)00143-2

Reference yield:

: 5688-96-0
N-phthalyl phenylglycine acid chloride

: 174536-94-8
N-phthalyl (R,R)-phenylglycine pantolactonyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NEt₃ / tetrahydrofuran / 0.42 h / -78 °C

2: tetrahydrofuran / 6 h / -78 °C

With triethylamine; In tetrahydrofuran;
DOI:10.1016/0040-4039(95)02170-1