octabenzyl 1D-2,6-di-O-benzyl-myo-inositol 1,3,4,5-tetrakisphosphate

Base Information

• Chemical Name: octabenzyl 1D-2,6-di-O-benzyl-myo-inositol 1,3,4,5-tetrakisphosphate
• CAS No.: 115015-98-0
• Molecular Formula: C₇₆H₇₆O₁₈P₄
• Molecular Weight: 1401.32
• Mol file: 115015-98-0.mol

Synonyms:octabenzyl 1D-2,6-di-O-benzyl-myo-inositol 1,3,4,5-tetrakisphosphate

Chemical Property of octabenzyl 1D-2,6-di-O-benzyl-myo-inositol 1,3,4,5-tetrakisphosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of octabenzyl 1D-2,6-di-O-benzyl-myo-inositol 1,3,4,5-tetrakisphosphate

There total 35 articles about octabenzyl 1D-2,6-di-O-benzyl-myo-inositol 1,3,4,5-tetrakisphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate (990-91-0) + racemic 2,4-di-O-benzyl-myo-inositol (16749-97-6,114419-12-4,115015-97-9,115184-74-2,118354-56-6,130404-34-1,149713-85-9,1214834-30-6) → (+/-) 2,6-di-O-benzyl-myo-inositol 1,3,4,5-tetrakis(dibenzylphosphate) (114342-99-3,115015-98-0,115184-75-3,118354-53-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 4h; Ambient temperature;

DOI:10.1016/S0040-4039(00)96548-1

Reference yield:

Phosphorous acid dibenzyl ester (1R,2S,3S,4R,5R,6S)-2,6-bis-benzyloxy-3,4,5-tris-(bis-benzyloxy-phosphanyloxy)-cyclohexyl ester (117666-33-8) → octabenzyl 1D-2,6-di-O-benzyl-myo-inositol 1,3,4,5-tetrakisphosphate (115015-98-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 2h; Yield given;

DOI:10.1016/S0008-6215(00)90549-4

Reference yield:

benzyl bromide (100-39-0) → octabenzyl 1D-2,6-di-O-benzyl-myo-inositol 1,3,4,5-tetrakisphosphate (115015-98-0)

Guidance literature:

Multi-step reaction with 8 steps

1: NaH / dimethylformamide

2: 1M HCl / acetone / 0.5 h / Heating

3: pyridine / 10 h / 20 °C

4: NaOH / methanol

5: potassium tert-butoxide / dimethylsulfoxide

6: 1M HCl / methanol / 0.25 h / Heating

7: 1H-tetrazole / acetonitrile; CH₂Cl₂ / 1 h / 20 °C

8: m-chloroperbenzoic acid / CH₂Cl₂ / 2 h / 20 °C

With pyridine; 1H-tetrazole; hydrogenchloride; sodium hydroxide; potassium tert-butylate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;

DOI:10.1016/S0008-6215(00)90549-4

upstream raw materials:

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

(-)-1L-2,6-di-O-benzyl-myo-inositol

Dibenzyl N,N-diisopropylphosphoramidite

Phosphorous acid dibenzyl ester (1R,2S,3S,4R,5R,6S)-2,6-bis-benzyloxy-3,4,5-tris-(bis-benzyloxy-phosphanyloxy)-cyclohexyl ester

Downstream raw materials:

myo-inositol 1,3,4,5-tetrakisphosphate

1D-2,6-Di-O-benzyl-myo-inositol 1,3,4,5-tetrakis(sodium benzyl phosphate)

octa-ammonium salt of D-myo-inositol 1,3,4,5-tetrakisphosphate

D-myo-inositol-1,3,4,5-tetrakisphosphate