octa-ammonium salt of D-myo-inositol 1,3,4,5-tetrakisphosphate

Base Information

• Chemical Name: octa-ammonium salt of D-myo-inositol 1,3,4,5-tetrakisphosphate
• CAS No.: 115016-66-5
• Molecular Formula: C₆H₈O₁₈P₄*8H₄N
• Molecular Weight: 636.321
• Mol file: 115016-66-5.mol

Synonyms:

Chemical Property of octa-ammonium salt of D-myo-inositol 1,3,4,5-tetrakisphosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of octa-ammonium salt of D-myo-inositol 1,3,4,5-tetrakisphosphate

There total 8 articles about octa-ammonium salt of D-myo-inositol 1,3,4,5-tetrakisphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

octabenzyl 1D-2,6-di-O-benzyl-myo-inositol 1,3,4,5-tetrakisphosphate (115015-98-0) → octa-ammonium salt of D-myo-inositol 1,3,4,5-tetrakisphosphate (115016-66-5,129832-37-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water;

DOI:10.1016/S0040-4039(00)96599-7

Reference yield:

D-myo-inositol (87-89-8) → octa-ammonium salt of D-myo-inositol 1,3,4,5-tetrakisphosphate (115016-66-5,129832-37-7)

Guidance literature:

Multi-step reaction with 11 steps

1: p-toluenesulfonic acid

2: 65 percent / CsF / dimethylformamide / 2 h / Ambient temperature

3: 85 percent / trifluoromethanesulfonic acid

4: 80 percent / ethylene glycol, p-TsOH / CHCl₃ / Ambient temperature

5: 96 percent / pyridine

6: aq AcOH / 90 - 100 °C

7: 37 percent / pyridine / 0.17 h / 0 °C

8: 66 percent / trifluoromethanesulfonic acid / CH₂Cl₂; cyclohexane

9: MeONa / methanol

10: 1.) butyl lithium / 1.) THF-DMSO, -40 deg C, 2.) 0 deg C, 2 h

11: 79 percent / H₂ / 5percent Pd/C / methanol; H₂O

With n-butyllithium; trifluorormethanesulfonic acid; hydrogen; sodium methylate; toluene-4-sulfonic acid; ethylene glycol; acetic acid; cesium fluoride; palladium on activated charcoal; In pyridine; methanol; dichloromethane; chloroform; cyclohexane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)96599-7

Reference yield:

1,2:4,5-dicyclohexylidene-myo-inositol (34361-60-9,55123-24-5,55123-26-7,62012-78-6,104873-71-4) → octa-ammonium salt of D-myo-inositol 1,3,4,5-tetrakisphosphate (115016-66-5,129832-37-7)

Guidance literature:

Multi-step reaction with 10 steps

1: 65 percent / CsF / dimethylformamide / 2 h / Ambient temperature

2: 85 percent / trifluoromethanesulfonic acid

3: 80 percent / ethylene glycol, p-TsOH / CHCl₃ / Ambient temperature

4: 96 percent / pyridine

5: aq AcOH / 90 - 100 °C

6: 37 percent / pyridine / 0.17 h / 0 °C

7: 66 percent / trifluoromethanesulfonic acid / CH₂Cl₂; cyclohexane

8: MeONa / methanol

9: 1.) butyl lithium / 1.) THF-DMSO, -40 deg C, 2.) 0 deg C, 2 h

10: 79 percent / H₂ / 5percent Pd/C / methanol; H₂O

With n-butyllithium; trifluorormethanesulfonic acid; hydrogen; sodium methylate; toluene-4-sulfonic acid; ethylene glycol; acetic acid; cesium fluoride; palladium on activated charcoal; In pyridine; methanol; dichloromethane; chloroform; cyclohexane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)96599-7

upstream raw materials:

octabenzyl 1D-2,6-di-O-benzyl-myo-inositol 1,3,4,5-tetrakisphosphate

D-myo-inositol

1,2:4,5-dicyclohexylidene-myo-inositol

(-)-1L-2,6-di-O-benzyl-myo-inositol