rac-8-cyclohexyl-N-((dimethylamino)sulfonyl)-1a-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Chemical Name:rac-8-cyclohexyl-N-((dimethylamino)sulfonyl)-1a-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide
CAS No.:1059609-01-6
Molecular Formula:C₃₅H₄₃N₅O₅S
Molecular Weight:645.823
Hs Code.:

rac-8-cyclohexyl-N-((dimethylamino)sulfonyl)-1a-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Synonyms:rac-8-cyclohexyl-N-((dimethylamino)sulfonyl)-1a-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Chemical Property of rac-8-cyclohexyl-N-((dimethylamino)sulfonyl)-1a-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Technology Process of rac-8-cyclohexyl-N-((dimethylamino)sulfonyl)-1a-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

There total 7 articles about rac-8-cyclohexyl-N-((dimethylamino)sulfonyl)-1a-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 959983-22-3
cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid, 8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxy-, (+/-)-

: 86732-22-1
2-benzyloctahydropyrrolo[3,4-c]pyrrole

: 1059609-01-6
rac-8-cyclohexyl-N-((dimethylamino)sulfonyl)-1a-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid, 8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxy-, (+/-)-; 2-benzyloctahydropyrrolo[3,4-c]pyrrole; With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

With hydrogenchloride; water; In N,N-dimethyl-formamide;

Reference yield:

: 494799-76-7
2-bromo-3-cyclohexyl-1H-indole-6-carboxylic acid

: 1059609-01-6
rac-8-cyclohexyl-N-((dimethylamino)sulfonyl)-1a-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 - 2.17 h / 22 - 50 °C

1.2: 21 - 24 h / 20 - 30 °C

2.1: sodium carbonate; lithium chloride / ethanol; water; toluene / 0.17 h

2.2: 70 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 55 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 30 °C

4.2: 0.5 h / 30 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.08 h / 90 °C / Microwave irradiation

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C

With sodium hydroxide; water; sodium hydride; sodium carbonate; caesium carbonate; triethylamine; HATU; 1,1'-carbonyldiimidazole; lithium chloride; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 494799-18-7
methyl 3-cyclohexyl-1H-indole-6-carboxylate

: 1059609-01-6
rac-8-cyclohexyl-N-((dimethylamino)sulfonyl)-1a-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2.67 h / 0 - 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 - 3 h / 90 °C / Heating / reflux

2.2: 1 h / 2 - 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 - 2.17 h / 22 - 50 °C

3.2: 21 - 24 h / 20 - 30 °C

4.1: sodium carbonate; lithium chloride / ethanol; water; toluene / 0.17 h

4.2: 70 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 55 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 30 °C

6.2: 0.5 h / 30 °C

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.08 h / 90 °C / Microwave irradiation

8.1: triethylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C

With lithium hydroxide; sodium hydroxide; pyridinium hydrobromide perbromide; water; sodium hydride; sodium carbonate; caesium carbonate; triethylamine; HATU; 1,1'-carbonyldiimidazole; lithium chloride; In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene;