8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Chemical Name:8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide
CAS No.:1059609-11-8
Molecular Formula:C₃₆H₄₅N₅O₅S
Molecular Weight:659.85
Hs Code.:

8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Synonyms:8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Chemical Property of 8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Technology Process of 8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

There total 9 articles about 8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1059609-01-6
rac-8-cyclohexyl-N-((dimethylamino)sulfonyl)-1a-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

: 1059609-11-8
8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: With sodium cyanoborohydride; In methanol; water; at 20 ℃; for 2h;

Reference yield:

: 494799-76-7
2-bromo-3-cyclohexyl-1H-indole-6-carboxylic acid

: 1059609-11-8
8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 - 2.17 h / 22 - 50 °C

1.2: 21 - 24 h / 20 - 30 °C

2.1: sodium carbonate; lithium chloride / ethanol; water; toluene / 0.17 h

2.2: 70 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 55 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 30 °C

4.2: 0.5 h / 30 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.08 h / 90 °C / Microwave irradiation

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C

7.1: sodium cyanoborohydride / methanol; water / 2 h / 20 °C

With sodium hydroxide; water; sodium hydride; sodium cyanoborohydride; sodium carbonate; caesium carbonate; triethylamine; HATU; 1,1'-carbonyldiimidazole; lithium chloride; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 494799-18-7
methyl 3-cyclohexyl-1H-indole-6-carboxylate

: 1059609-11-8
8-cyclohexyl-N-((dimethylamino)sulfonyl)-11-methoxy-1a-((5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2.67 h / 0 - 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 - 3 h / 90 °C / Heating / reflux

2.2: 1 h / 2 - 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 - 2.17 h / 22 - 50 °C

3.2: 21 - 24 h / 20 - 30 °C

4.1: sodium carbonate; lithium chloride / ethanol; water; toluene / 0.17 h

4.2: 70 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 55 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 30 °C

6.2: 0.5 h / 30 °C

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.08 h / 90 °C / Microwave irradiation

8.1: triethylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C

9.1: sodium cyanoborohydride / methanol; water / 2 h / 20 °C

With lithium hydroxide; sodium hydroxide; pyridinium hydrobromide perbromide; water; sodium hydride; sodium cyanoborohydride; sodium carbonate; caesium carbonate; triethylamine; HATU; 1,1'-carbonyldiimidazole; lithium chloride; In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene;