2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole

Base Information

• Chemical Name: 2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole
• CAS No.: 133040-04-7
• Molecular Formula: C₂₅H₃₀N₂O₅S
• Molecular Weight: 470.59
• Mol file: 133040-04-7.mol

Synonyms:2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole

Chemical Property of 2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole

There total 10 articles about 2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 3-(2-thienyl)propanoate (16862-05-8) + 2-n-butyl-1-[(4-carbomethoxyphenyl)methyl]-1H-imidazol-5-carboxaldehyde (133040-03-6) → 2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole (133040-04-7)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1021/jm00108a043

Reference yield:

Methyl 4-(bromomethyl)benzoate (2417-72-3) → 2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole (133040-04-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / K₂CO₃ / dimethylformamide / 17 h / 80 °C

2: 96 percent / H₂, NaOAc / 10percent Pd/C / methanol / 18 h

3: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, 30 min

With hydrogen; sodium acetate; potassium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1080/00397919308011184

Reference yield:

2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde (83857-96-9) → 2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole (133040-04-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / K₂CO₃ / dimethylformamide

2: 97 percent / H₂, KOAc / Pd/C / methanol

3: 98 percent / LDA / tetrahydrofuran

With hydrogen; potassium acetate; potassium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00108a043

upstream raw materials:

methyl 3-(2-thienyl)propanoate

2-n-butyl-1-[(4-carbomethoxyphenyl)methyl]-1H-imidazol-5-carboxaldehyde

2-butyl-1H-imidazole

Methyl 4-(bromomethyl)benzoate

Downstream raw materials:

4-[5-(1-Acetoxy-2-methoxycarbonyl-3-thiophen-2-yl-propyl)-2-butyl-imidazol-1-ylmethyl]-benzoic acid methyl ester

eprosartan

methyl (E)-3-<2-butyl-1-<(4-carbomethoxyphenyl)methyl>imidazol-5-yl>-2-(2-thienylmethyl)-2-propenoate

SB 206328