(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(((tert-butoxycarbonyl) amino)methyl)phenyl)-N-methoxy-N-methylpropionamide

Base Information

Chemical Name:(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(((tert-butoxycarbonyl) amino)methyl)phenyl)-N-methoxy-N-methylpropionamide
CAS No.:1394024-96-4
Molecular Formula:C₂₅H₃₃N₃O₆
Molecular Weight:471.554
Hs Code.:

Synonyms:(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(((tert-butoxycarbonyl) amino)methyl)phenyl)-N-methoxy-N-methylpropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(((tert-butoxycarbonyl) amino)methyl)phenyl)-N-methoxy-N-methylpropionamide

Chemical Property:

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Technology Process of (S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(((tert-butoxycarbonyl) amino)methyl)phenyl)-N-methoxy-N-methylpropionamide

There total 6 articles about (S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(((tert-butoxycarbonyl) amino)methyl)phenyl)-N-methoxy-N-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1394024-95-3
(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)propanoic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1394024-96-4
(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(((tert-butoxycarbonyl) amino)methyl)phenyl)-N-methoxy-N-methylpropionamide

Guidance literature:: With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h;
DOI:10.1021/jm3016987

Reference yield:

: NH(Me)OMe_.HCl

: O-(1H-6-Chlorobenzotriazolyl)-1,1,3,3-tetramethyluronium hexafluorophosphate

: 1394024-95-3
(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)propanoic acid

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: 1394024-96-4
(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(((tert-butoxycarbonyl) amino)methyl)phenyl)-N-methoxy-N-methylpropionamide

Guidance literature:: In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate;

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1394024-96-4
(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(((tert-butoxycarbonyl) amino)methyl)phenyl)-N-methoxy-N-methylpropionamide

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 1 h / 20 - 25 °C

2: sodium carbonate / water; 1,4-dioxane / 4 h / pH 9

3: sodium hydroxide / water; ethanol / 1 h

4: sodium carbonate / tetrahydrofuran / 3 h / 0 - 20 °C / pH 9

5: 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h

With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); sulfuric acid; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;
DOI:10.1021/jm3016987