2-amino-N-cyclopropyl-3-(2-(2,4-dichlorophenyl)-2-oxoethyl)-3H-imidazo[4,5-b]pyridine-5-carboxamide

Base Information

Chemical Name:2-amino-N-cyclopropyl-3-(2-(2,4-dichlorophenyl)-2-oxoethyl)-3H-imidazo[4,5-b]pyridine-5-carboxamide
CAS No.:1616406-53-1
Molecular Formula:C₁₈H₁₅Cl₂N₅O₂
Molecular Weight:404.255
Hs Code.:

Synonyms:2-amino-N-cyclopropyl-3-(2-(2,4-dichlorophenyl)-2-oxoethyl)-3H-imidazo[4,5-b]pyridine-5-carboxamide

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Chemical Property of 2-amino-N-cyclopropyl-3-(2-(2,4-dichlorophenyl)-2-oxoethyl)-3H-imidazo[4,5-b]pyridine-5-carboxamide

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Technology Process of 2-amino-N-cyclopropyl-3-(2-(2,4-dichlorophenyl)-2-oxoethyl)-3H-imidazo[4,5-b]pyridine-5-carboxamide

There total 7 articles about 2-amino-N-cyclopropyl-3-(2-(2,4-dichlorophenyl)-2-oxoethyl)-3H-imidazo[4,5-b]pyridine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.3%

: 1616406-52-0
2-amino-N-cyclopropyl-3H-imidazo[4,5-b]pyridine-5-carboxamide

: 4252-78-2
2,2',4'-trichloroacetophenone

: 1616406-53-1
2-amino-N-cyclopropyl-3-(2-(2,4-dichlorophenyl)-2-oxoethyl)-3H-imidazo[4,5-b]pyridine-5-carboxamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm500535j

Reference yield:

: 538372-32-6
6-amino-5-nitro-pyridine-2-carboxylic acid methyl ester

: 1616406-53-1
2-amino-N-cyclopropyl-3-(2-(2,4-dichlorophenyl)-2-oxoethyl)-3H-imidazo[4,5-b]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 120 °C / Inert atmosphere; Microwave irradiation

2: hydrogen; palladium on activated charcoal / methanol / 3 h / 20 °C / Inert atmosphere

3: potassium carbonate / water; ethanol / 13 h / 80 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; potassium carbonate; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm500535j

Reference yield:

: 21901-29-1
6-amino-5-nitro-2-picoline

: 1616406-53-1
2-amino-N-cyclopropyl-3-(2-(2,4-dichlorophenyl)-2-oxoethyl)-3H-imidazo[4,5-b]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: N,N-dimethyl-formamide / 16 h / 140 °C / Inert atmosphere

2: potassium permanganate; potassium carbonate / water; tert-butyl alcohol / 3.17 h / Inert atmosphere

3: sulfuric acid / 12 h / Reflux

4: ethanol / 120 °C / Inert atmosphere; Microwave irradiation

5: hydrogen; palladium on activated charcoal / methanol / 3 h / 20 °C / Inert atmosphere

6: potassium carbonate / water; ethanol / 13 h / 80 °C / Inert atmosphere

7: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With potassium permanganate; sulfuric acid; palladium on activated charcoal; hydrogen; potassium carbonate; In methanol; ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm500535j