538372-32-6

Usage

Uses

Used in Pharmaceutical and Chemical Research:
2-Pyridinecarboxylic acid, 6-amino-5-nitro-, methyl ester (9CI) is used as a research compound for studying its interactions with certain biological targets, such as enzymes and receptors. Its potential therapeutic applications are being explored due to these interactions.
Used as an Intermediate in Organic Synthesis:
2-Pyridinecarboxylic acid, 6-amino-5-nitro-, methyl ester (9CI) is used as an intermediate in the synthesis of various organic compounds. Its functional groups allow for further chemical reactions and modifications, making it a valuable component in the development of new chemical entities.
Safety Precautions:
It is important to handle 2-Pyridinecarboxylic acid, 6-amino-5-nitro-, methyl ester (9CI) with care due to its potential hazards, including skin and eye irritation. It should be used in a well-ventilated area with appropriate safety measures in place to minimize any risks associated with its use.

Upstream product

• 353277-27-7 6-chloro-5-nitropyridine-2-carboxylic acid 
• 21901-29-1 6-amino-5-nitro-2-picoline 
• 67-56-1 methanol 
• 84487-06-9 6-amino-5-nitropyridine-2-carboxylic acid 
• 201230-82-2 carbon monoxide 
• 84487-04-7 6-bromo-3-nitro-pyridin-2-ylamine 

Downstream Products

• 4093-31-6 methyl 2-methoxy 4-acetamido 5-chloro benzoate 
• 538372-36-0 2-(4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-yl)-3H-imidazo[4,5-b]pyridine-5-carboxylic acid 
• 538372-35-9 2-(4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-yl)-3H-imidazo[4,5-b]pyridine-5-carboxylic acid methyl ester 
• 538372-33-7 5,6-diamino-pyridine-2-carboxylic acid methyl ester 
• 1616406-00-8 2-amino-N-cyclopropyl-3-(2-(2,4-dichlorophenyl)-2-hydroxyethyl)-3H-imidazo[4,5-b]pyridine-5-carboxamide 
• 1616406-53-1 2-amino-N-cyclopropyl-3-(2-(2,4-dichlorophenyl)-2-oxoethyl)-3H-imidazo[4,5-b]pyridine-5-carboxamide 
• 892873-38-0 (6-amino-5-nitro-pyridine-2-yl)methanol 

Relevant academic research and scientific papers

HETEROCYCLIC GLP-1 AGONISTS

Provided are GLP-1 agonists of Formula (I) or (II), including pharmaceutically acceptable salts and solvates thereof, pharmaceutical compositions, and methods of using the same.

Lithium Hexamethyldisilazane Transformation of Transiently Protected 4-Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation

Trimethylsilyl-transient protection successfully allowed the use of lithium hexamethyldisilazane to prepare benzimidazole (BI) and 4-azabenzimidazole (azaBI) amidines from nitriles in 58-88% yields. This strategy offers a much better choice to prepare BI/azaBI amidines than the lengthy, low-yielding Pinner reaction. Synthesis of aza/benzimidazole rings from aromatic diamines and aldehydes was affected in dimethyl sulfoxide in 10-15 min, while known procedures require long time and purification. These methods are important for the BI/azaBI-based drug industry and for developing specific DNA binders for expanded therapeutic applications.

FUSED TRIAZOLE DERIVATIVES AS PHOSPHODIESTERASE 10A INHIBITORS

Compounds of the general formula (I), wherein one of X1 and X2 represents N, and the other one of X1 and X2 represents -C(CH3), A represents unsubstituted or substituted 5-, 6-or 10-membered aryl or h

Aminoazabenzimidazoles, a Novel Class of Orally Active Antimalarial Agents

Whole-cell high-throughput screening of the AstraZeneca compound library against the asexual blood stage of Plasmodium falciparum (Pf) led to the identification of amino imidazoles, a robust starting point for initiating a hit-to-lead medicinal chemistry effort. Structure-activity relationship studies followed by pharmacokinetics optimization resulted in the identification of 23 as an attractive lead with good oral bioavailability. Compound 23 was found to be efficacious (ED90 of 28.6 mg·kg-1) in the humanized P. falciparum mouse model of malaria (Pf/SCID model). Representative compounds displayed a moderate to fast killing profile that is comparable to that of chloroquine. This series demonstrates no cross-resistance against a panel of Pf strains with mutations to known antimalarial drugs, thereby suggesting a novel mechanism of action for this chemical class.

Synthesis and inhibitory activity of benzoic acid and pyridine derivatives on influenza neuraminidase

Based upon the activity and X-ray crystallographic studies of tri-substituted benzene derivatives containing carboxylic acid, acetamido and guanidine groups, we investigated the effect of the fourth substituent to fulfill the fourth pocket of neuraminidas

Alternative heterocycles for DNA recognition

Methods and compositions are provided for forming complexes between dsDNA and novel oligomers comprising fused six-membered rings. By appropriate choice of target sequences and oligomers, complexes comprising oligomer-DNA are obtained with high association constants. The formation of complexes can be used for identification of specific dsDNA sequences, for inhibiting gene transcription, and as a therapeutic for inhibiting proliferation of undesired cells or modulation of expression of specific genes.

Imidazopyridine/pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition

The DNA binding properties of fused heterocycles imidazo[4,5-b]pyridine (Ip) and hydroxybenzimidazole (Hz) paired with pyrrole (Py) in eight-ring hairpin polyamides are reported. The recognition profile of Ip/Py and Hz/Py pairs were compared to the five-m