(E)-(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pent-2-enoic acid methyl ester

Base Information

Chemical Name:(E)-(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pent-2-enoic acid methyl ester
CAS No.:122911-33-5
Molecular Formula:C₂₂H₂₉NO₅
Molecular Weight:387.476
Hs Code.:

Synonyms:(E)-(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pent-2-enoic acid methyl ester

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Chemical Property of (E)-(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pent-2-enoic acid methyl ester

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Technology Process of (E)-(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pent-2-enoic acid methyl ester

There total 9 articles about (E)-(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pent-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

: 122911-32-4
(2R,3R)-3-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-3-methoxy-2-methyl-propionaldehyde

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 122911-33-5
(E)-(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pent-2-enoic acid methyl ester

Guidance literature:: In dichloromethane; for 48h; Heating;
DOI:10.1039/P19900000047

Reference yield:

: 128836-47-5
(2R,3R)-3-(2,5-Dimethoxy-3-nitro-phenyl)-3-hydroxy-2-methyl-propionic acid methyl ester

: 122911-33-5
(E)-(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pent-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / NaH / tetrahydrofuran; dimethylformamide / 16 h / -5 °C

2: 100 percent / H₂ / 10percent Pd-C / ethanol / 2.5 h / 760 Torr

3: 91 percent / isobutyric acid / toluene / 65 h / Heating

4: 100 percent / LiAlH₄ / tetrahydrofuran / 3 h / -5 °C

5: 89 percent / SO₃*Py, Et₃N / dimethylsulfoxide; tetrahydrofuran / 0.75 h / 25 °C

6: 99.5 percent / CH₂Cl₂ / 24 h / 40 °C

With lithium aluminium tetrahydride; pyridine-SO₃ complex; hydrogen; sodium hydride; triethylamine; isobutyric Acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 122911-29-9
(2R,3R)-3-(2,5-Dimethoxy-3-nitro-phenyl)-3-methoxy-2-methyl-propionic acid methyl ester

: 122911-33-5
(E)-(4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pent-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / H₂ / 10percent Pd-C / ethanol / 2.5 h / 760 Torr

2: 91 percent / isobutyric acid / toluene / 65 h / Heating

3: 100 percent / LiAlH₄ / tetrahydrofuran / 3 h / -5 °C

4: 89 percent / SO₃*Py, Et₃N / dimethylsulfoxide; tetrahydrofuran / 0.75 h / 25 °C

5: 99.5 percent / CH₂Cl₂ / 24 h / 40 °C

With lithium aluminium tetrahydride; pyridine-SO₃ complex; hydrogen; triethylamine; isobutyric Acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; toluene;