2-BROMO-5-METHOXYBENZYLAMINE

Base Information

• Chemical Name: 2-BROMO-5-METHOXYBENZYLAMINE
• CAS No.: 887581-09-1
• Molecular Formula: C8H10 Br N O
• Molecular Weight: 216.077
• Mol file: 887581-09-1.mol

Synonyms:1-(2-Bromo-5-methoxyphenyl)methanamine

Chemical Property of 2-BROMO-5-METHOXYBENZYLAMINE

Chemical Property:

• PSA: 35.25000
• LogP: 2.61670
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-5-methoxybenzylamine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-5-METHOXYBENZYLAMINE

There total 5 articles about 2-BROMO-5-METHOXYBENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromo-5-methoxy-benzaldehyde (7507-86-0) → (2-bromo-5-methoxyphenyl)methanamine (887581-09-1)

Guidance literature:

2-bromo-5-methoxy-benzaldehyde; With tert-butyldimethylsilane; methyl carbamate; trifluoroacetic acid; In acetonitrile; at 80 ℃; for 6h;

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 80 ℃; for 16h;

DOI:10.1016/j.tet.2011.12.060

Reference yield: 90.0%

2-bromo-5-methoxybenzyl bromide (19614-12-1) → (2-bromo-5-methoxyphenyl)methanamine (887581-09-1)

Guidance literature:

With ammonia; In ethanol; water; at 20 ℃; for 4h;

DOI:10.1055/s-0028-1083502

Reference yield: 89.0%

2-bromo-5-methoxybenzyl azide → (2-bromo-5-methoxyphenyl)methanamine (887581-09-1)

Guidance literature:

2-bromo-5-methoxybenzyl azide; With triphenylphosphine; In tetrahydrofuran; for 1h; Reflux;

With water; In tetrahydrofuran; for 1h; Reflux;

DOI:10.1002/chem.200900942

upstream raw materials:

2-bromo-5-methoxybenzonitrile

2-bromo-5-methoxybenzamide

2-bromo-5-methoxybenzyl bromide

2-bromo-5-methoxy-benzaldehyde

Downstream raw materials:

tert-butyl (2-bromo-5-methoxybenzyl)carbamate

C₁₂H₁₄BrNO₂

1-(2-bromo-5-methoxybenzyl)-5-hexyl-3,4-dihydropyridin-2(1H)-one

1-(2-bromo-5-methoxybenzyl)-5-(4-methylbenzyl)-3,4-dihydropyridin-2(1H)-one

Refernces

• 1、 Satyanarayana, Gedu,Maier, Martin E.. "Tricyclic isoindolines by Heck cyclization". supporting information; experimental part. p. 1745 - 1749. Retrieved 2012/03/10.
• 2、 Majumdar,Mondal, Shovan,De, Nirupam. "Synthesis of polycyclic sultams by palladium-catalyzed intramolecular cyclization". scheme or table. p. 3127 - 3135. Retrieved 2009/12/27.