Technology Process of tert-butyl 2-((2S,3R)-6,6,6-trifluoro-3-((S,Z)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamoyl)-2-(3,3,3-trifluoropropyl)hexanamidothio) ethylcarbamate
There total 13 articles about tert-butyl 2-((2S,3R)-6,6,6-trifluoro-3-((S,Z)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamoyl)-2-(3,3,3-trifluoropropyl)hexanamidothio) ethylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
di-tert-butyl(disulfanediylbis(ethane-2,1-diyl))dicarbamate;
With
silver nitrate;
In
methanol;
at 24 ℃;
for 0.333333h;
(2R,3S)-N-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3- trifluoropropyl)succinamide;
With
triethylamine;
for 4h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 - 25 °C / Autoclave; Inert atmosphere
2.1: N,N-dimethyl-formamide / 20 - 25 °C / Inert atmosphere
2.2: 20 - 25 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere
4.1: ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / Inert atmosphere
5.1: silver nitrate / methanol / 0.33 h / 24 °C
5.2: 4 h
With
palladium 10% on activated carbon; hydrogen; ammonium chloride; benzotriazol-1-ol; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide
2.1: trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere
3.1: ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / Inert atmosphere
4.1: silver nitrate / methanol / 0.33 h / 24 °C
4.2: 4 h
With
ammonium chloride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
